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Horm Metab Res 1983; 15(12): 620-622
DOI: 10.1055/s-2007-1018808
© Georg Thieme Verlag, Stuttgart · New York

Selective Alteration of Secretin-Stimulated Cardiac Adenylate Cyclase Activity in Streptozotocin-Diabetic Rats

P. Chatelain1 , L. Gillet, M. Waelbroeck, J. C. Camus, P. Robberecht, J. Christophe2
  • 1Continental Pharma Research Laboratories, Mont Saint-Guibert, Belgium
  • 2Department of Biochemistry and Nutrition, Medical School, Université Libre de Bruxelles, Brussels, Belgium
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Publication History

1983

1983

Publication Date:
14 March 2008 (online)

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Summary

Secretin stimulation of adenylate cyclase activity in heart membranes was selectively altered in streptozotocin-diabetic adult male rats suffering from moderately severe diabetes, 40 days after i.v. streptozotocin administration (40 mg/kg body weight). The efficacy of secretin was reduced by 55% whilst its potency was unaffected. By contrast, the stimulation of adenylate cyclase by NaF, GTP, Gpp(NH)p, D,L-isoproterenol, and glucagon remained normal. The present data, together with the markedly reduced secretin response of cardiac adenylate cyclase in genetically obese (fa/fa) Zucker rats might indicate that hypoinsulinemia and insulin resistance both reduce the number of secretin receptors coupled to the adenylate cyclase system, an alteration whose contribution to diabetic cardiomyopathy remains to be determined.

Key-Words:

Rat Heart - Adenylate Cyclase - Secretin - Streptozotocin - Diabetes - Hormone Receptor