Subscribe to RSS
DOI: 10.1055/s-2007-963222
© Georg Thieme Verlag KG Stuttgart · New York
Die Eignung der hochfrequenten Sonografie zur Diagnostik des DCIS
The Suitability of High-Resolution Ultrasound for the Detection of DCISPublication History
eingereicht: 3.12.2006
angenommen: 4.5.2007
Publication Date:
22 June 2007 (online)

Zusammenfassung
Ziel: Darstellung der Wertigkeit der hochfrequenten Mammasonografie zur Diagnostik des DCIS. Material und Methoden: Literaturüberblick und Beschreibung der sonografischen Merkmale des DCIS mit Illustrationen. Ergebnisse: Die Sonografie kann heute insgesamt das DCIS in einer zur Mammografie vergleichbaren Größenordnung detektieren. Besondere Fähigkeiten der Sonografie zeigen sich bei mammografisch okkulten DCIS ohne Mikrokalk und DCIS in dichten bis sehr dichten Mammae. Der sonografischen Beurteilung der Drüsenarchitektur ganzer Lobi kommt neben der Detektion umschriebener Herdbefunde steigende Bedeutung zu. Schlussfolgerung: Die Sonografie stellt neben der Mammografie eine wichtige Methode in der Diagnostik des DCIS dar.
Abstract
Purpose: Presentation of the suitability of breast ultrasound for detecting DCIS of the breast. Materials and Methods: Review of literature on the topic and description of the sonographic features of DCIS illustrated by cases. Results: Breast ultrasound is currently capable of detecting DCIS with a comparable success rate to that of mammography. The advantages of sonography become obvious in cases of DCIS without microcalcifications and DCIS in dense or very dense breasts. The assessment of the sonographic architecture of the whole lobe, not just circumscribed lesions, is becoming increasingly important. Conclusion: Breast ultrasound represents an important tool for detecting DCIS in addition to mammography.
Key words
mammography - dcis - breast ultrasound - breast cancer - microcalcifications
Literatur
- 1
Radford D M, Philipps N HJ, Fair K L. et al .
Allelic loss and the progression of breast cancer.
Cancer Res.
1995;
55
5180-5183
MissingFormLabel
- 2
Stratton M R, Collins N, Lakhani S R. et al .
Loss of heterozygosity in ductal carcinoma in situ of the breast.
J Pathol.
1995;
175
195-201
MissingFormLabel
- 3
Hannemann J, Velds A, Halfwerk J BG. et al .
Classification of ductal carcinoma in situ by gene expression profiling.
Breast Cancer Res.
2006;
8
R61; doi: 10.1186/brc1613
MissingFormLabel
- 4
Ernster V L, Barclay J, Kerlikowske K. et al .
Incidence of and treatment for ductal carcinoma in situ of the breast.
JAMA.
1996;
275
913-918
MissingFormLabel
- 5
Ernster V L, Ballard-Barbasch R, William E B. et al .
Detection of ductal carcinoma in situ in women undergoing screening mammography.
J Natl Cancer Inst.
2002;
94
1546-1554
MissingFormLabel
- 6
Barchielli A, Federico M, De Lisi V. et al .
In situ breast cancer: incidence trend and organised screening programmes in Italy.
Eur J Cancer.
2005;
41
1045-1050
MissingFormLabel
- 7 Teboul M, Hallwell M. Atlas of ultrasound and ductal echography of the breast. London; Blackwell Science 1995
MissingFormLabel
- 8
Kolb T M, Lichy J, Newhouse J H.
Occult Cancer in women with dense breasts: detection with screening US-diagnostic
yield and tumor characteristics.
Radiology.
1998;
207
191-199
MissingFormLabel
- 9
Buchberger W, DeKoekkoek-Doll P, Springer P. et al .
Incidental findings on sonography of the breast: clinical significance and diagnostic
workup.
AJR.
1999;
173
921-927
MissingFormLabel
- 10
Kaplan S S.
Clinical utility of bilateral whole-breast US in the evaluation of women with dense
breast tissue.
Radiology.
2001;
221
641-649
MissingFormLabel
- 11
Schoonjans J M, Brem F R.
Sonographic appearance of ductal carcinoma in situ diagnosed with ultrasonographically
guided large core needle biopsy.
J Ultrasound Med.
2000;
19
449-457
MissingFormLabel
- 12
Moon W K, Myung J S, Lee Y J. et al .
US of Ducal Carcinoma In Situ.
RadioGraphics.
2002;
22
269-281
MissingFormLabel
- 13 Stavros A T. Ultrasound of Ductal Carcinoma in Situ. Silverstein ML Ductal Carcinoma in Situ of the Breast Philadelphia. Lippincott; Williams & Wilkins 2002 Second edition: 129-169
MissingFormLabel
- 14 Stavros A T. Malignant solid breast nodules: specific types. Stavros AT Breast Ultrasound Philadelphia: Lippincott; Williams & Wilkins 2004: 598-612
MissingFormLabel
- 15
Chen S C, Cheung Y C, Lo Y F. et al .
Sonographic differentiation of invasive and intraductal carcinomas of the breast.
BJR.
2003;
76
600-604
MissingFormLabel
- 16
Yang W T, Tse G MK.
Sonographic, mammographic, and histopathologic correlation of symptomatic ductal carcinoma
in situ.
AJR.
2004;
182
101-110
MissingFormLabel
- 17
Moon W K, Dong-Yang N, Jung-Gi I.
Multifocal, multicentric, and contralateral breast cancers: bilateral whole-breast
US in the preoperative evaluation of patients.
Radiology.
2002;
224
596-576
MissingFormLabel
- 18
LaTrenta L R, Menell J H, Morris E A. et al .
Breast lesions detected with MR imaging: utility and histopathologic importance of
identification with US.
Radiology.
2003;
227
856-861
MissingFormLabel
- 19
Berg W A, Gutierrez L, Nessaiver M S. et al .
Diagnostic accuracy of mammography, clinical examination, US, and MR imaging in preoperative
assessment of breast cancer.
Radiology.
2004;
233
830-849
MissingFormLabel
- 20
Grunert J H, Hille H.
Mammasonographie und Mammographie in der dezentralen Brustkrebsdiagnostik.
GebFra.
2006;
66
670-673
MissingFormLabel
- 21
Sardanelli F, Giuseppetti G M, Panizza P. et al .
Sensitivity of MRI versus mammography for detecting foci of multifocal multicentric
breast cancer in fatty and dense breasts using the whole-breast pathologic examination
as a gold standard.
AJR.
2004;
183
1149-1157
MissingFormLabel
- 22
Bluemke D A, Gatsonis C A, Chen M H. et al .
Magnetic resonance imaging prior to biopsy.
JAMA.
2004;
292
2735-2742
MissingFormLabel
- 23
Menell J H, Morris E A, Dershaw D D. et al .
Determination of the presence and extent of pure ductal carcinoma in situ by mammography
and magnetic resonance imaging.
Breast J.
2005;
11
382-390
MissingFormLabel
- 24 Leucht W. Lehratlas der Mammasonographie. Stuttgart; Thieme 1989
MissingFormLabel
- 25 Ultraschallvereinbarung der KBV (Anlage 3 BMV-Ä/EKV) vom 10.2.1993. www.kbv.de/rechtsquellen
MissingFormLabel
- 26
Marquet K L, Wolter M, Handt S. et al .
Mammasonographische Dignitätskriterien unter besonderer Berücksichtigung der Tumorgröße.
Ultraschall in Med.
2002;
23
383-387
MissingFormLabel
- 27
Schulz-Wendtland R, Bock K, Aichinger U. et al .
Mamma-Sonographie mit 7,5MHz versus 13 MHz: Ist eine Verbesserung der diagnostischen
Sicherheit im Rahmen der komplementären Mammadiagnostik möglich?.
Ultraschall in Med.
2005;
26
209-215
MissingFormLabel
- 28
Morgan M P, Cooke M M, Mc Carthy G M.
Microcalcifications associated with breast cancer: an epiphenomenon or biologically
significant feature of selected tumors?.
J Mammmary Gland Biol Neoplasia.
2005;
10
181-187
MissingFormLabel
- 29
Seymour H R, Cooke J, Given-Wilson R.
The significance of spontaneous resolution of breast calcification.
BJR.
1999;
72
3-8
MissingFormLabel
- 30
Barreau B, Mascarel de I, Feuga C. et al .
Mammography of ductal carcinoma in situ of the breast: review of 909 cases with radiographic-pathologic
correlations.
Eur J Radiol.
2005;
54
55-61
MissingFormLabel
- 31
Mulz D, Egger H, Knupfer A. et al .
Mikrokalk im Mammogramm und Darstellungsmöglichkeit im Ultraschall.
GebFra.
1981;
41
255-258
MissingFormLabel
- 32 Kasumi F, Tanaka H. Detection of microcalcifications in breast carcinoma by ultrasound. Jellins J, Kobayashi T Ultrasound examination of the breast New York; John Wiley &Sons 1983: 89-97
MissingFormLabel
- 33
Harper P, Kelly-Fry E.
Ultrasound visualisation of the breast in symptomatic patients.
Radiology.
1980;
137
465-469
MissingFormLabel
- 34
Lambie R W, Hodgdan D, Herman E M. et al .
Sonomammographic manifestations of mammographically detectable breast microcalcifications.
J Ultrasound Med.
1983;
2
509-514
MissingFormLabel
- 35
Potterton A J, Peakman D J, Young J R.
Ultrasound demonstration of small breast cancers detected by mammographic screening.
Clin Radiol.
1994;
49
808-813
MissingFormLabel
- 36 Dudwiesus H. Persönliche Mitteilung,. Solingen; GE Healthcare
MissingFormLabel
- 37
Kasumi F.
Can microcalcifications located within breast carcinomas be detected by ultrasound
imaging?.
Ultrasound Med Biol.
1988;
14 Suppl 1
175-182
MissingFormLabel
- 38
Anderson M E, Soo M S, Bentley R C. et al .
The detection of breast microcalcifications with medical ultrasound.
J Acoust Soc Am.
1997;
101
29-39
MissingFormLabel
- 39
Yang W T, Suen M, Ahuja A. et al .
In vivo demonstration of microcalcifications in breast cancer using high resolution
ultrasound.
BJR.
1997;
70
685-690
MissingFormLabel
- 40
Moon W K, Im J G, Koh Y H. et al .
US of mammographically detected clustered microcalcifications.
Radiology.
2000;
217
849-854
MissingFormLabel
- 41
Gufler H, Buitrago-Tellez C H, Madjar H. et al .
Ultrasound demonstration of mammographically detected microcalcifications.
Acta Radiol.
2000;
41
217-221
MissingFormLabel
- 42
Hashimoto B E, Kramer D J, Picozzi V J.
High detection rate of breast ductal carcinoma in situ calcifications on mammographically
directed high-resolution sonography.
J Ultrasound Med.
2001;
20
501-508
MissingFormLabel
- 43
Cheung Y C, Wan Y L, Chen S C. et al .
Sonographic evaluation of mammographically detected microcalcifications without a
mass prior to stereotactic core needle biopsy.
J Clin Ultrasound.
2002;
30
323-331
MissingFormLabel
- 44
Soo M S, Baker J A, Rosen E L.
Sonographic detection and sonographically guided biopsy of breast microcalcifications.
AJR.
2003;
180
941-948
MissingFormLabel
- 45
Marini C, Traino C, Cilotti A. et al .
Differentiation of benign and malignant breast microcalcifications: mammography versus
mammography-sonography combination.
Radiol Med.
2003;
105
17-26
MissingFormLabel
- 46
Nagashima T, Hashimoto H, Oshida K. et al .
Ultrasound demonstration of mammographically detected microcalcifications in patients
with ductal carcinoma in situ of the breast.
Breast Cancer.
2005;
12
216-220
MissingFormLabel
- 47
Tot T.
DCIS, cytokeratins, and the theory of the sick lobe.
Virchows Arch.
2005;
447
1-8
MissingFormLabel
- 48
Madjar H, Ohlinger R, Mundinger A. et al .
BI-RADS analoge DEGUM Kriterien von Ultraschallbefunden der Brust - Konsensus des
Arbeitskreises Mammasonographie der DEGUM.
Ultraschall in Med.
2006;
27
374-379
MissingFormLabel
- 49
Ohlinger R, Klein G M, Köhler G.
Ultrasound of the breast - value of sonographic criteria for the differential diagnosis
of solid lesions.
Ultraschall in Med.
2004;
25
48-53
MissingFormLabel
Dr. Heino Hille
Praxis für Frauenheilkunde
Lappenbergsallee 50
20257 Hamburg
Phone: ++49/40/40 33 40
Fax: ++49/40/49 43 36
Email: heino.hille@t-online.de