Int J Sports Med 2008; 29(3): 257-263
DOI: 10.1055/s-2007-965127
Genetics & Molecular Biology

© Georg Thieme Verlag KG Stuttgart · New York

The COL12A1 and COL14A1 Genes and Achilles Tendon Injuries

A. V. September1 , M. Posthumus1 , L. van der Merwe2 , M. Schwellnus1 , T. D. Noakes1 , M. Collins1 , 3
  • 1UCT/MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Cape Town, South Africa
  • 2Biostatistics Research Unit, South African Medical Research Council, Cape Town, South Africa
  • 3Exercise Science and Sports Medicine Research Unit, South African Medical Research Council, Cape Town, South Africa
Further Information

Publication History

accepted after revision January 11, 2007

Publication Date:
25 October 2007 (online)

Abstract

Genes encoding for tenascin C and a subunit of type V collagen have previously been reported to be associated with Achilles tendon injuries. Types XII and XIV collagen may be involved in similar biological processes as these proteins in tendons. The aim of this study was therefore to test the association between polymorphisms within COL12A1 and COL14A1 and Achilles tendon injuries. Restriction fragment length polymorphism (RFLP) analysis was used to identify the relative frequencies of two polymorphisms within each of the COL12A1 and COL14A1 genes within 137 subjects with clinical symptoms of Achilles tendon injuries, consisting of 93 with Achilles tendinopathy and 44 with Achilles tendon rupture, and 131 asymptomatic control subjects. No statistically significant differences were identified in the genotype, allele or haplotype distributions between the affected and control subjects. The findings from this study suggest that although COL12A1 and COL14A1 are involved in similar biological processes as TNC and COL5A1, the polymorphisms tested are not associated with clinical symptoms of Achilles tendon injury within the investigated population.

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Dr. PhD Malcolm Collins

Exercise Science and Sports Medicine Research Unit South African Medical Research Council

PO Box 115

Newlands 7725

South Africa

Fax: + 27 216 86 75 30

Email: malcolm.collins@mrc.ac.za