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Int J Sports Med 2008; 29(3): 194-198
DOI: 10.1055/s-2007-965163
Physiology & Biochemistry

© Georg Thieme Verlag KG Stuttgart · New York

Fluid Restriction during Running Increases GI Permeability

G. P. Lambert1 , J. Lang1 , A. Bull1 , P. C. Pfeifer1 , J. Eckerson1 , G. Moore1 , S. Lanspa2 , J. O'Brien2
  • 1Exercise Science and Athletic Training, Creighton University, Omaha, Nebraska, United States
  • 2Department of Medicine, Creighton University, Omaha, Nebraska, United States
Further Information

Publication History

accepted after revision February 12, 2007

Publication Date:
05 July 2007 (online)

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Abstract

The purpose of this study was to determine gastrointestinal (GI) permeability during prolonged treadmill running (60 min at 70 % V·O2max) with and without fluid intake (3 ml/kg body mass/10 min). Twenty runners (11 males, 9 females; age = 22 ± 3 (SD) yrs; mean V·O2max = 55.7 ± 5.0 ml/kg/min) completed four experiments: 1) rest, 2) running with no fluid (NF), 3) running with ingestion of a 4 % glucose solution (GLU), and 4) running with ingestion of a water placebo (PLA). To determine GI permeability, subjects also drank a solution containing 5 g sucrose (S), 5 g lactulose (L), and 2 g rhamnose (R) immediately prior to each trial. Gastroduodenal permeability was determined by urinary S excretion, while small intestinal permeability was determined by the L/R excretion ratio. Percent body mass loss (i.e., dehydration) was negligible during rest, GLU and PLA, while NF resulted in a 1.5 % loss of body mass (p < 0.05). Gastroduodenal and intestinal permeability were significantly (p < 0.008) increased in NF compared to rest. There were no other differences in GI permeability. These results indicate that fluid restriction during 1 h of steady-state running increases GI permeability above resting levels.

Key words

exercise - intestine - permeability

References

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Dr. Ph.D. G. Patrick Lambert

Exercise Science and Athletic Training
Creighton University

2500 California Plaza, Room 225 KFC

Omaha, NE 68178

USA

Phone: + 1 40 22 80 24 20

Fax: + 1 40 22 80 47 32

Email: plambert@creighton.edu