Stereoselective Synthesis of a Mevinic Acid Analogue [1]

Abstract

An efficient and versatile synthetic method for the stereoselective synthesis of a mevinic acid analogue is described. This approach uses a combination of a Cosford protocol with a catecholborane-mediated stereoselective reduction of acyclic β-hydroxy ketones to syn-1,3-diols, as key steps.

mevinic acid analogue - Cosford protocol - β-hydroxy ketones - catecholborane - syn-1,3-diols

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