Facile Synthesis of Unsymmetrical 1,n′-Disubstituted Ferrocenoyl Amino Acid Derivatives by Palladium-Catalyzed Aminocarbonylation

Abstract

Various unsymmetrical 1,n′-disubstituted ferrocenoyl amino acids were obtained by palladium-catalyzed aminocarbon­ylation starting from 1,1′-diiodoferrocene. The reactions were carried out in one-pot, using an equimolar mixture of two amino acid esters as nucleophiles. The structures of the products were determined by ¹H NMR, ¹³C NMR, IR and MS analyses. Each was found to adopt an ordered, intramolecularly hydrogen bonded conformation.

Key words

ferrocene - amino acids - carbonylations - palladium - homogeneou­s catalysis

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