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Aktuelle Dermatologie 2007; 33(11): 413-416
DOI: 10.1055/s-2007-967005
Übersicht

© Georg Thieme Verlag KG Stuttgart · New York

Der Beitrag von Keratinozyten an der Pathogenese des kutanen Lupus erythematodes[*]

Contribution of Keratinocytes to the Pathogenesis of Cutaneous Lupus ErythematosusM.  Wittmann1
  • 1Klinik und Poliklinik für Dermatologie und Venerologie der Medizinischen Hochschule Hannover
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Publication History

Publication Date:
12 November 2007 (online)

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Zusammenfassung

Hautveränderungen sind eine häufige Manifestationsform der Autoimmunerkrankung Lupus erythematodes (LE). Derzeit steht keine kurative Therapie zur Verfügung. Eine Voraussetzung für die Entwicklung einer effektiven Lokaltherapie besteht in einem besseren Verständnis der zugrunde liegenden Pathomechanismen. Keratinozyten werden als Zielzellen des auto-aggressiven Angriffs gesehen. Es mehren sich jedoch die Hinweise, dass Keratinozyten auch - mittels Mediatorfreisetzung - aktiv an der Regulation und Aufrechterhaltung der Lupuspathologie beteiligt sind. In der vorgestellten Untersuchung haben wir das pro-entzündliche Antwortmuster von Keratinozyten von LE-Patienten im Vergleich zu Keratinozyten von gesunden Spendern untersucht.

Abstract

Lupus erythematosus (LE) is an autoimmune disorder and cutaneous manifestations belong to the most common clinical features of LE. Up to now, there exists no causative treatment regimen. However, a prerequisite for development of effective local therapeutics is the better understanding of the underlying pathophysiological mechanisms. In cutaneous LE (CLE), keratinocytes are considered to be target cells for immunological injury. Next to their role as target cells, evidence is accumulating that keratinocytes play an important role in actively regulating and maintaining the pathology in CLE by virtue of mediator release. In this study, we were interested in determining differences in the proinflammatory response of patient-derived keratinocytes.

1 Förderung durch die Deutsche Forschungsgemeinschaft (Wi1822/5-1).
Vortrag beim wissenschaftlichen Jahres-Symposium der Berliner Stiftung für Dermatologie, 12. Mai 2007, Berlin.

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1 Förderung durch die Deutsche Forschungsgemeinschaft (Wi1822/5-1).
Vortrag beim wissenschaftlichen Jahres-Symposium der Berliner Stiftung für Dermatologie, 12. Mai 2007, Berlin.

Prof. Dr. med. Miriam Wittmann

Klinik und Poliklinik für Dermatologie und Venerologie
der Medizinischen Hochschule Hannover

Ricklinger Straße 5
30449 Hannover

Email: Wittmann.Miriam@MH-Hannover.de