Synlett 2007(2): 0215-0218  
DOI: 10.1055/s-2007-967997
LETTER
© Georg Thieme Verlag Stuttgart · New York

A New Organocatalytic Process of Cyclotrimerization of Acetylenic Ketones Mediated by 2,4-Pentanedione

Qing-Fa Zhou, Fei Yang, Qing-Xiang Guo, Song Xue*
Department of Chemistry, University of Science and Technology of China, Hefei, 230026, P. R. of China
Fax: +86(551)3606689; e-Mail: xuesong@ustc.edu.cn;
Further Information

Publication History

Received 24 September 2006
Publication Date:
24 January 2007 (online)

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Abstract

A new organocatalytic process of cyclotrimerization of the aliphatic and aromatic acetylenic ketones was developed. The reaction catalyzed by DMAP in the presence of 2,4-pentanedione gave 1,3,5-trisubstituted benzenes in almost quantitative yields ­under very mild conditions. 2,4-Pentanedione was used as a co-­catalyst to promote the reaction efficiently, particularly for aliphatic acetylenic ketones.