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Planta Med 1983; 49(11): 158-161
DOI: 10.1055/s-2007-969838
Research Articles

© Hippokrates Verlag Stuttgart

Etude complémentaire de la cytotoxicité de la mélinonine F, alcaloïde dérivé de la β-carboline

Complementary Study of Cytotoxic Activity of Melinonine FR. Bassleer1 , J.-M. Marnette1 , Ph. Wiliquet1 , M.-Cl. De Pauw-Gillet1 , M. Caprasse2 , L. Angenot2
  • 1Service d'Histologie et Cytologie, Faculté de Médecine, Université de Liège, Belgique
  • 2Laboratoire de Pharmacognosie, Institut de Pharmacie, Université de Liège, Belgique
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Publication History

1983

1983

Publication Date:
26 March 2007 (online)

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Abstract

The cellular effects of melinonine F, an alkaloid isolated from Strychnos melinoniana (South America) and Strychnos usambarensis (Central Africa), are analysed in cancer or normal cells in culture. A cytotoxic action is noted in both types of cells, at least for relatively high concentrations. These effects are probably due to interaction of the drug with chromatin. Physico-chemical analysis demonstrates partial intercalation of melinonine F on pure DNA in vitro.

Key Word Index

Strychnos species - Loganiaceae - Indole alkaloids - Melinonine F - Cytotoxic agents - Cancer cells - DNA - Intercalation