Expression of IGF System Genes During T-Antigen Driven Pituitary Tumorigenesis

A. Grewal; S. L. Bradshaw; A. G. P. Schuller; M. J. Low; J. E. Pintar

doi:10.1055/s-2007-978714

Hormone and Metabolic Research, Inhaltsverzeichnis

Horm Metab Res 1999; 31(2/03): 155-160
DOI: 10.1055/s-2007-978714

Expression of IGF System Genes During T-Antigen Driven Pituitary Tumorigenesis

A. Grewal¹ , S. L. Bradshaw¹ , A. G. P. Schuller¹ , M. J. Low² , J. E. Pintar¹

¹University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Department of Neuroscience and Cell Biology, Piscataway, NJ, USA
²Vollum Institute, L-474 (MJL), Oregon Health Sciences University, Portland, OR, USA

Abstract

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Expression of IGF-I, IGF-II, the Type-I IGF receptor and six IGF binding proteins were examined in three different T-agdriven mouse tumors. Unlike the widespread expression of IGF-II in pancreatic β-cell tumors, IGF-II was not widely expressed in the two different pituitary tumors examined indicating that a mechanism independent of focal IGF-II expression can also drive T-antigen tumorigenesis. In addition, multiple IGF binding proteins were expressed in all three tumor types. This expression, however, was generally heterogeneous with no specific changes to indicate a required role for any IGF binding protein in T-antigen tumorigenesis.

Key words

Insulin-Like Growth Factors - T-Antigen - Pituitary - Binding Proteins

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