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Synthesis 2007(18): 2797-2802
DOI: 10.1055/s-2007-983871
DOI: 10.1055/s-2007-983871
PAPER
© Georg Thieme Verlag Stuttgart · New York
Studies toward the Total Synthesis of (-)-Dictyostatin: Stereoselective Preparation of the C1-C10 Fragment [1]
Further Information
Publication History
Received
22 May 2007
Publication Date:
29 August 2007 (online)
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Abstract
The efficient synthesis of the C1-C10 fragment of (-)-dictyostatin has been achieved by Evans-Tischenko reduction of a β-hydroxy ketone, followed by cross metathesis and Z-olefination. The β-hydroxy ketone is easily synthesized diastereoselectively by allylation and dihydroxylation of an alcohol.
Key words
diastereoselectivity - Evans-Tischenko reduction - β-hydroxy ketones - Wittig olefination - cross metathesis
DRL Publication No. 622.