Abstract
The efficient synthesis of the C1-C10 fragment of (-)-dictyostatin has been achieved by Evans-Tischenko reduction of a β-hydroxy ketone, followed by cross metathesis and Z-olefination. The β-hydroxy ketone is easily synthesized diastereoselectively by allylation and dihydroxylation of an alcohol.
Key words
diastereoselectivity - Evans-Tischenko reduction - β-hydroxy ketones - Wittig olefination - cross metathesis
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