RSS-Feed abonnieren
DOI: 10.1055/s-2007-985614
© Georg Thieme Verlag KG Stuttgart · New York
Konzeptionelle Therapieansätze bei Arthrose
Therapeutic concepts for osteoarthritisPublikationsverlauf
                     eingereicht: 16.7.2007
                     
                     akzeptiert: 9.8.2007
                     
Publikationsdatum:
07. September 2007 (online)

Zusammenfassung
Heutzutage wird die Arthrose als multifaktorielles Geschehen aufgefasst, das Kriterien der systemischen, chronisch-entzündlichen Erkrankungen aufweist. Ansätze in der Therapie bestehen präventiv, konservativ, medikamentös - auch mit Biologicals -, lokal (intraartikulär), genetisch und operativ.
Therapeutic concepts for osteoarthritis
Today osteoarthritic changes are understood as a systemic disease with multifactorial influences comparable to the systemic arthritis illnesses. Therapeutic goals aim to preventive measures, conservative treatment, medicaments - also „biologicals” -, local (intraarticular) injections, genetic and surgicals interventions.
Schlüsselwörter
Arthrose - Therapie - Medikamente - genetische Faktoren - Operationen
Key words
osteoarthritis - therapy - medicaments - genetic factors - surgery
Literatur
- 1 
            Aaron R. et al .
            Arthroscopic débridement for osteoarthritis of the knee. 
            J Bone Joint Surgery. 
            2006; ; 
            88-A (5) 
            936-943 
            
            Reference Ris Wihthout Link
- 2 
            Bell C. et al .
            Self assembling peptides as injectable lubricants for osteoarthritis. 
            J Biomed Mater Res. 
            2006; 
            78 
            236-246 
            
            Reference Ris Wihthout Link
- 3 
            Cannon C. et al .
            Multinational etoricoxib and diclofenac arthritis long-term (MEDAL) programme: a randomized
            comparison. 
            Lancet. 
            2006; 
            368 
            1771-1781 
            
            Reference Ris Wihthout Link
- 4 
            Chevalier X. et al .
            Safety study of intrarticular injection of interleukin-1-receptor-antagonist in patients
            with painful knee osteoarthritis: a multicenter study. 
            J Rheumatol. 
            2005; 
            32 
            1317-1323 
            
            Reference Ris Wihthout Link
- 5 
            Clegg D. et al .
            Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. 
            New Engl J Med. 
            2006; 
            354 
            795-808 
            
            Reference Ris Wihthout Link
- 6 
            Forsyth C. et al .
            Increased matrix metalloproteinase-13 production with aging by human articular chondrocytes
            in response to catabolic stimuli. 
            J Gerontol Biol Sci 60A. 
            2005; 
            9 
            1118-1124 
            
            Reference Ris Wihthout Link
- 7 
            Martin J. et al .
            Posttraumatic osteoarthritis: the role of stress induced chondrocyte damage. 
            Biorheology. 
            2006; 
            (43) 
             
            517-521 
            
            Reference Ris Wihthout Link
- 8 
            McIntosh A. et al .
            Recent intraarticular steroid injection may increase infection rates in primary THA. 
            Clin Orthop Rel Res. 
            2006; 
            451 
            50-54 
            
            Reference Ris Wihthout Link
- 9 
            Michel B. et al .
            Chondroitins 4 and 6 sulfate in osteoarthritis of the knee. A randomized, controlled
            trial. 
            Arthritis & Rheumatism. 
            2005; 
            52 (3) 
            779-786 
            
            Reference Ris Wihthout Link
- 10 
            Nehrer S. et al .
            Histologic analysis of tissue after failed cartilage repair procedures. 
            Clin Orthop. 
            1999; 
            365 
            149-162 
            
            Reference Ris Wihthout Link
- 11 
            Petrella R. et al .
            A prospective, randomized, double-blind, placebo-controlled study to evaluate the
            efficacy of intraarticular hyaluronic acid for osteoarthritis of the knee. 
            J Rheumatol. 
            2006; 
            33 
            951-956 
            
            Reference Ris Wihthout Link
- 12 
            Pottie P. et al .
            Obesity and osteoarthritis: more complex than predicted!. 
            Ann Rheum Dis. 
            2006; 
            65 
            1403-1405 
            
            Reference Ris Wihthout Link
- 13 
            Roskos S. 
            Intraarticular corticosteroids for treating osteoarthritis of the knee. 
            Amer Family Phys. 
            2005; 
            72 (7) 
            1222-1223 
            
            Reference Ris Wihthout Link
- 14 
            Tehranzadeh J. et al .
            Cartilage metabolism in osteoarthritis and the influence of viscosupplemantation and
            steroids: a review. 
            Acta Radiologica. 
            2005; 
            3 
            287-296 
            
            Reference Ris Wihthout Link
Prof. Dr. med. St. Rehart
         Klinik für Orthopädie und Unfallchirurgie, Markus-Krankenhaus, Akademisches Lehrkrankenhaus
         der J.W.-Goethe-Universität Frankfurt
         
         W.-Epstein-Str. 2
         
         60431 Frankfurt am Main
         
         Telefon: 069/9533-2540
         
         Fax: 069/9533-2417
         
         eMail: Rehart@fdk.info
         
         
 
     
      
    