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DOI: 10.1055/s-2007-986628
Molybdenum Hexacarbonyl and DBU Reduction of Nitro Compounds under Microwave Irradiation
Publikationsverlauf
Publikationsdatum:
23. August 2007 (online)
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Abstract
An ethanolic mixture of molybdenum hexacarbonyl and DBU mediates the reduction of nitroarenes to the corresponding anilines in excellent yields in 15-30 minutes under microwave irradiation.
Key words
amines - microwave - molybdenum - nitroarenes - reductions
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Typical Work-up
After solvent concentration, the resulting crude product is passed over a short SiO2 plug (6 cm × 3 cm). Typical eluent: neat CH2Cl2 to 5:1 CH2Cl2-acetone gradient. All products were characterised by 1H NMR, 13C NMR, GC-MS, or MS and correspond to commercial samples or literature values (see ref. 7b and also ref. 9). Compound 2o: 1H NMR (270 MHz): δ = 3.67 (2 H, br s), 4.67 (2 H, s), 6.54 (1 H, d, J = 8.4 Hz), 6.78 (1 H,s), 7.07 (1 H, s), 7.11 (1 H, s). 13C NMR (67 MHz): δ = 62.9, 115.1, 121.1, 129.8, 138.7, 145.4. -
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The Aldrich Library of 13C and 1H FT NMR Spectra
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References and Notes
Spencer, J.; Rathnam, R. P.; Patel, H.; Anjum, N., manuscript in preparation.