Biflavones of Decussocarpus rospigliosii as Phosphodiesterases Inhibitors

Abstract

A phytochemical study of an ethyl acetate extract of Decussocarpus rospigliosii leaves led to the isolation of six 3′-8′′-biapigenin derivatives identified as amentoflavone (1), podocarpusflavone A (2), sequoiaflavone (3), podocarpusflavone B (4), 7,7′′-di-O-methylamentoflavone (5) and heveaflavone (6). Biflavones 1 - 4 showed strong inhibitory activity on several PDE isoforms. Biflavone (5) showed selective and potent inhibition of the PDE4 isoform (IC₅₀ = 1.48 ± 0.21 μM) and was almost as active as the reference drug Rolipram (IC₅₀ = 1.1 ± 0.2 μM).

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