Progress in Coenzyme NADH Model Compounds and Asymmetric Reduction of Benzoylformate

Abstract

Nicotinamide adenine dinucleotide hydrogen (NADH) could play an important role in living systems and this has stimulated a great deal of interest in the fields of bioorganic and organic chemistry. A large number of NADH model compounds have been developed for studying stereoselective reduction. Herein, the factors involved in stereoselective reduction using NADH model compounds are discussed and the progress of research on coenzyme NADH model compounds is summarized.

1 Introduction

2 Factors of Stereoselective Reduction Using NADH Models

2.1 Effect of a Remote Sterically Demanding Side Chain

2.2 Effect of a Substituent at C-4 of the Dihydropyridine Ring

2.3 Effect of a Special Conformation

3 Conclusion

Key words

nicotinamide adenine dinucleotide hydrogen - NADH - coenzyme - stereoselectivity - reduction

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