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Synthesis 2008(1): 69-74
DOI: 10.1055/s-2007-990903
DOI: 10.1055/s-2007-990903
PAPER
© Georg Thieme Verlag Stuttgart · New York
Synthesis of Chiral Pyridyl Alcohols Using a Two-Step Catalytic Approach
Weitere Informationen
Received
14 September 2007
Publikationsdatum:
15. November 2007 (online)
Publikationsverlauf
Publikationsdatum:
15. November 2007 (online)
![](https://www.thieme-connect.de/media/synthesis/200801/lookinside/thumbnails/10.1055-s-2007-990903-1.jpg)
Abstract
Chiral pyridyl alcohols have been prepared by developing a two-step approach that uses the asymmetric cyanation of aldehydes to give cyanohydrins and subsequent [2+2+2]-cyclotrimerization reaction with acetylene.
Key words
asymmetric synthesis - cyclotrimerization - cyanohydrin - pyridine - aldehyde
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