Synthesis of Chiral Pyridyl Alcohols Using a Two-Step Catalytic Approach

Barbara Heller; Dmitry Redkin; Andrey Gutnov; Christine Fischer; Werner Bonrath; Reinhard Karge; Marko Hapke

doi:10.1055/s-2007-990903

PAPER

Synthesis of Chiral Pyridyl Alcohols Using a Two-Step Catalytic Approach

Barbara Heller*^a, Dmitry Redkin^a, Andrey Gutnov^b, Christine Fischer^a, Werner Bonrath^c, Reinhard Karge^c, Marko Hapke*^a
^a Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Str. 29a, 18059 Rostock, Germany
Fax: +49(381)12815000; e-Mail: barbara.heller@catalysis.de; marko.hapke@catalysis.de;
^b ChiroBlock GmbH, Andresenstr. 1a, 06766 Wolfen, Germany
^c DSM Nutritional Products Ltd., Process Research NRD-CR, P.O. Box 3255, Bldg. 214/1.57, 4002 Basel, Switzerland

Abstract

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Abstract

Chiral pyridyl alcohols have been prepared by developing a two-step approach that uses the asymmetric cyanation of aldehydes to give cyanohydrins and subsequent [2+2+2]-cyclotrimerization reaction with acetylene.

Key words

asymmetric synthesis - cyclotrimerization - cyanohydrin - pyridine - aldehyde

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References

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