Diastereoselective Conjugate Radical Additions to β-Pyranones

Abstract

We have developed a convenient protocol for functionalization of β-pyranones. Conjugate radical addition and tandem addition-trapping protocols allow for accessing highly substituted pyrones in a single operation with high selectivity.

Key words

radical reaction - β-pyranones - diastereoselectivity - conjugate addition - tandem reactions

References and Notes

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7

All new compounds showed analytical and spectral characteristics consistent with their structure. An experimental procedure and spectral data for select products are provided.