Abstract
Phytochemical investigation of a high potency variety of Cannabis sativa L. resulted in the isolation of six new metabolites, (±)-6,7-trans-epoxycannabigerolic acid (2), (±)-6,7-cis-epoxycannabigerolic acid (3), (±)-6,7-cis-epoxycannabigerol (4), (±)-6,7-trans-epoxycannabigerol (5), 5′-methyl-4-pentylbiphenyl-2,2′,6-triol (7), and 7-methoxycannabispirone (8), along with seven known compounds namely, cannabigerolic acid (1), 5′-methoxycannabigerolic acid (6), cannabispirone (9), β-cannabispiranol (10), dehydrocannabifuran (11), cannflavin B (12) and cannabigerol (13). The antimicrobial as well as the antileishmanial activities were investigated.
Abbreviations
CBG:cannabigerol
CBD:cannabidiol
FID:flame ionization detector
Δ9-THC:Δ9-tetrahydrocannabinol
VLC:vacuum liquid chromatography
Key words
Cannabis sativa
- Cannabaceae - epoxy cannabigerolic acid - cannabispirone - antimicrobial activity - antileishmanial activity
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Dr. Samir A. Ross
National Center for Natural Products Research
School of Pharmacy
The University of Mississippi
University
MS 38677
USA
Phone: +1-662-915-1031
Fax: +1-662-915-7989
Email: sross@olemiss.edu
