Long Cui1, 6
, Phuong Thien Thuong2, 6
, Hyun Sun Lee1
, Dieudonné Njamen3
, Joseph Tanyi Mbafor3
, Z. Tanee Fomum3
, Junwon Lee4
, Young Ho Kim5
, Won Keun Oh2
1Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Korea
2College of Pharmacy, Chosun University, Gwangju, Korea
3Yaounde I University, Yaounde, Cameroon
4Department of Genetic Engineering, Paichai University, Daejeon, Korea
5College of Pharmacy, Chungnam National University, Daejeon, Korea
6These authors contributed equally to this work
Further Information
Publication History
Received: January 3, 2008
Revised: January 22, 2008
Four new chalcones 1 - 4, named abyssinones A - D, were isolated from the stem bark of the plant Erythrina abyssinica and their structures were elucidated on the basis of spectroscopic analyses. The compounds 1, 3, and 4 were found to exhibit moderate cytotoxic activity against the human colorectal cancer cell line (Caco2) with IC50 values of 13.3, 15.1, and 11.1 μM, respectively.
2
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