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Synlett 2008(7): 949-957
DOI: 10.1055/s-2008-1042907
DOI: 10.1055/s-2008-1042907
ACCOUNT
© Georg Thieme Verlag Stuttgart · New York
Recent Advances in Direct Arylation via Palladium-Catalyzed Aromatic C-H Activation
Weitere Informationen
Received
22 October 2007
Publikationsdatum:
11. März 2008 (online)
Publikationsverlauf
Publikationsdatum:
11. März 2008 (online)
![](https://www.thieme-connect.de/media/synlett/200807/lookinside/thumbnails/10.1055-s-2008-1042907-1.jpg)
Abstract
Highly selective arylation catalyzed by palladium and directed by the acetamino group provides an efficient and practical protocol for constructing unique biaryl scaffolds, which could be further transformed into different structural units found in a range of natural products.
1 Introduction
2 Highly Regioselective Halogenation
3 Highly Regioselective Arylation
3.1 With Arylboronic Acids
3.2 With Trialkoxyarylsilanes
3.3 With Simple Arenes
3.4 Further Transformations
4 Conclusion
Key words
C-H activation - arylation - palladium - catalysis - acetanilide
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