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Synthesis 2008(8): 1276-1282
DOI: 10.1055/s-2008-1042949
DOI: 10.1055/s-2008-1042949
PAPER
© Georg Thieme Verlag Stuttgart · New York
One-Pot Synthesis of 6-(Pyridyl)salicylates by Formal [3+3] Cyclizations of 1,3-Bis(silyl enol ethers) with 3-Pyridyl-3-silyloxy-2-en-1-ones
Weitere Informationen
Received
29 November 2007
Publikationsdatum:
18. März 2008 (online)
Publikationsverlauf
Publikationsdatum:
18. März 2008 (online)
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Abstract
6-(Pyridyl)salicylates were regioselectively prepared by formal [3+3] cyclization of 1,3-bis(silyl enol ethers) with 3-(pyridyl)-3-silyloxy-2-en-1-ones. These reactions represent what are, to the best of our knowledge, the first [3+3] cyclizations of 1,3-bis(silyl enol ethers) with heterocyclic substrates.
Key words
cyclizations - heterocycles - regioselectivity - pyridines - silyl enol ethers
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