The Stereoselective Synthesis of the C6-C18 Fragment of Scytophycin C Employing a Novel Synthetic Methodology

Abstract

A novel synthetic approach towards the stereoselective synthesis of the C6-C18 fragment of the biologically active anti­tumor agent scytophycin C is described. The synthesis involves Marouka­ allylation, base-catalyzed intramolecular conjugate addition, Wittig olefination, and a tandem allylation.

Key words

scytophycin - allylation - olefination - trans-2,6-disubstituted dihydropyran

References

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Scytophycins isolated from other species of Scytonema and Cylindrospermum musicola see: refs. 3b and 3c.