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Neuropediatrics 1989; 20(2): 103-106
DOI: 10.1055/s-2008-1071274
DOI: 10.1055/s-2008-1071274
Case report
© Georg Thieme Verlag KG Stuttgart · New York
Familial Occurrence of Prenatal Encephaloclastic Damage: Anatomoclinical Report of 2 Cases
Further Information
Publication History
Publication Date:
19 March 2008 (online)

Abstract
Two brothers had a congenital cerebral malformation suggestive of a destructive process of the parenchyma; the first was hydranencephalic with extensive heterotopias. The second had focal microgyria and subcortical heterotopias. The precise origin of this disorder, which occurred two times in the same sibship, was not found; there is no reported genetic disease capable to cause such destructive brain lesion. The possibility of a persistent infectious disorder causing repetitive disturbance of gestation is discussed; it has not been proved. A fortuitous association cannot be excluded.
Key words
Familial hydranencephaly - Prenatal encephaloclastic damage