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Synlett 2008(9): 1391-1393
DOI: 10.1055/s-2008-1072767
DOI: 10.1055/s-2008-1072767
LETTER
© Georg Thieme Verlag Stuttgart · New York
Efficient Synthesis of 2-Substituted Benzoxazoles via Beckmann Rearrangement of 2-Hydroxyaryl Ketoximes Using Diethyl Chlorophosphate
Weitere Informationen
Received
21 August 2007
Publikationsdatum:
07. Mai 2008 (online)
Publikationsverlauf
Publikationsdatum:
07. Mai 2008 (online)
![](https://www.thieme-connect.de/media/synlett/200809/lookinside/thumbnails/10.1055-s-2008-1072767-1.jpg)
Abstract
An efficient method for synthesis of 2-substituted benzoxazoles has been developed using diethyl chlorophosphate. 2-Hydroxyaryl ketoximes are efficiently converted to benzoxazoles by heating in the presence of diethyl chlorophosphate via Beckmann rearrangement of ketoxime in excellent yields. This method avoids the use of strong acids, harsh conditions, and long reaction times.
Key words
benzoxazoles - Beckmann rearrangement - cyclization - 2-hydroxyaryl ketoximes - diethyl chlorophosphate
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