Phytochemical Investigation of Anaphalis lactea

Abstract

Four new compounds, 2′,6′-dihydroxy-3′-(2-hydroxy-3-methyl-3-butenyl)-4′-methoxychalcone (1), 4,6-dihydroxy-7-isobutyryl-5-prenyl-2(3H)-benzofuranone (4), 7-O-(β-D-glucopyranosyloxy)-5-hydroxy-1(3H)-isobenzofuranone (6) and (2R,3S)-3-methyl-2-(5-oxo-2-isopropenylhexyl)-cyclopentanone (7), along with thirteen known compounds were isolated from the whole plant of Anaphalis lactea. Their structures were established based on spectroscopic methods including IR, UV, MS, CD, 1 D NMR and 2 D NMR techniques. Compounds 2, 4 – 6 and 8 – 16 were tested for free-radical scavenging properties in the DPPH assays.

Key words

Anaphalis lactea - Compositae - chalcones - benzofuranones - phthalide glucosides - sesquiterpenes - antioxidant property

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