Cardiovascular risk factors in idiopathic compared to riskassociated venous thromboembolism: A focus on fibrinogen, factor VIII, and high-sensitivity C-reactive protein (hs-CRP)

Beate Luxembourg; Joern Schmitt; Marek Humpich; Matthias Glowatzki; Dejan Dressler; Erhard Seifried; Edelgard Lindhoff-Last

doi:10.1160/TH-09-02-0104

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2009; 102(04): 668-675
DOI: 10.1160/TH-09-02-0104

Blood Coagulation, Fibrinolysis and Cellular Haemostasis

Schattauer GmbH

Cardiovascular risk factors in idiopathic compared to riskassociated venous thromboembolism: A focus on fibrinogen, factor VIII, and high-sensitivity C-reactive protein (hs-CRP)

Beate Luxembourg

¹Department of Internal Medicine, Division of Vascular Medicine and Haemostaseology, University Hospital Frankfurt, Germany

,

Joern Schmitt

²Department of Internal Medicine, Division of Cardiology, University Hospital Frankfurt, Germany

,

Marek Humpich

³Department of Anesthesiology, Intensive Care Medicine and Pain Management, University Hospital Frankfurt, Germany

,

Matthias Glowatzki

⁴SPSS GmbH München, Germany

,

Dejan Dressler

¹Department of Internal Medicine, Division of Vascular Medicine and Haemostaseology, University Hospital Frankfurt, Germany

,

Erhard Seifried

⁵Institute of Transfusion Medicine and Immunohematology, Blood Transfusion Center of the German Red Cross, Frankfurt, Germany

,

Edelgard Lindhoff-Last

¹Department of Internal Medicine, Division of Vascular Medicine and Haemostaseology, University Hospital Frankfurt, Germany

› Author Affiliations

Abstract

Summary

There have recently been reports of an increased incidence of arterial cardiovascular events in patients with idiopathic venous thromboembolism (VTE) compared to patients with risk-associated VTE. The aim of our study was to evaluate whether elevated clotting factors, which have been linked to chronic subclinical inflammation and arterial thromboembolic disease, have a higher prevalence in idiopathic VTE compared to secondary VTE.Plasma fibrinogen,factor VIII,and high-sensitivity C-reactive protein (hs-CRP) levels were determined in a cohort of sex and age-matched patients with unprovoked VTE (n=101), patients with secondary VTE (n=101), and controls (n=202). Fibrinogen and hs-CRP levels were higher in patients with idiopathic VTE (fibrinogen: median/range: 331/214-524 mg/dl; hs-CRP: median/interquartile range: 1.8/0.8-3.7 mg/l) than in those with risk-associated VTE (299/162-458 mg/dl, p=0.004; 1.5/0.8-2.2 mg/l, p=0.05) and controls (302/185-644 mg/dl, p=0.001; 1.2/0.5-2.2

Keywords

Venous thrombosis - fibrinogen - factor VIII - C-reactive protein

Full Text

References

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