Cardiovascular risk factors in idiopathic compared to riskassociated venous thromboembolism: A focus on fibrinogen, factor VIII, and high-sensitivity C-reactive protein (hs-CRP)

Beate Luxembourg; Joern Schmitt; Marek Humpich; Matthias Glowatzki; Dejan Dressler; Erhard Seifried; Edelgard Lindhoff-Last

doi:10.1160/TH-09-02-0104

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2009; 102(04): 668-675
DOI: 10.1160/TH-09-02-0104

Blood Coagulation, Fibrinolysis and Cellular Haemostasis

Schattauer GmbH

Cardiovascular risk factors in idiopathic compared to riskassociated venous thromboembolism: A focus on fibrinogen, factor VIII, and high-sensitivity C-reactive protein (hs-CRP)

Authors

Beate Luxembourg

¹Department of Internal Medicine, Division of Vascular Medicine and Haemostaseology, University Hospital Frankfurt, Germany
Joern Schmitt

²Department of Internal Medicine, Division of Cardiology, University Hospital Frankfurt, Germany
Marek Humpich

³Department of Anesthesiology, Intensive Care Medicine and Pain Management, University Hospital Frankfurt, Germany
Matthias Glowatzki

⁴SPSS GmbH München, Germany
Dejan Dressler

¹Department of Internal Medicine, Division of Vascular Medicine and Haemostaseology, University Hospital Frankfurt, Germany
Erhard Seifried

⁵Institute of Transfusion Medicine and Immunohematology, Blood Transfusion Center of the German Red Cross, Frankfurt, Germany
Edelgard Lindhoff-Last

¹Department of Internal Medicine, Division of Vascular Medicine and Haemostaseology, University Hospital Frankfurt, Germany

Abstract

Summary

There have recently been reports of an increased incidence of arterial cardiovascular events in patients with idiopathic venous thromboembolism (VTE) compared to patients with risk-associated VTE. The aim of our study was to evaluate whether elevated clotting factors, which have been linked to chronic subclinical inflammation and arterial thromboembolic disease, have a higher prevalence in idiopathic VTE compared to secondary VTE.Plasma fibrinogen,factor VIII,and high-sensitivity C-reactive protein (hs-CRP) levels were determined in a cohort of sex and age-matched patients with unprovoked VTE (n=101), patients with secondary VTE (n=101), and controls (n=202). Fibrinogen and hs-CRP levels were higher in patients with idiopathic VTE (fibrinogen: median/range: 331/214-524 mg/dl; hs-CRP: median/interquartile range: 1.8/0.8-3.7 mg/l) than in those with risk-associated VTE (299/162-458 mg/dl, p=0.004; 1.5/0.8-2.2 mg/l, p=0.05) and controls (302/185-644 mg/dl, p=0.001; 1.2/0.5-2.2

Keywords

Venous thrombosis - fibrinogen - factor VIII - C-reactive protein

Full Text

References

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