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DOI: 10.1160/TH03-05-0302
Regulatory roles of androgens in cutaneous wound healing
Financial support: This work was supported by The Wellcome TrustPublikationsverlauf
Received
19. Mai 2003
Accepted after revision
08. Juli 2003
Publikationsdatum:
05. Dezember 2017 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00035024/200306/lookinside/thumbnails/10-1160-th03-05-0302-1.jpg)
Summary
Although the effects of androgens on wound healing are poorly characterised, the androgen receptor is expressed by inflammatory cells, keratinocytes and fibroblasts during wound healing, suggesting that androgens may regulate inflammatory and/or repair processes. In fact, it appears that endogenous testosterone inhibits wound healing and promotes inflammation since castration of male mice or systemic treatment with the androgen receptor antagonist flutamide accelerates cutaneous wound healing and reduces the inflammatory response. The aim of this review is to summarise our current knowledge about the regulation of tissue repair processes by androgens.
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