The factor VII activating protease G511E (Marburg) variant and cardiovascular risk

Helen Ireland; George J. Miller; Karen E.Webb; Jackie A. Cooper; Steve E. Humphries

doi:10.1160/TH04-05-0275

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2004; 92(05): 986-992
DOI: 10.1160/TH04-05-0275

Blood Coagulation, Fibrinolysis and Cellular Haemostasis

Schattauer GmbH

The factor VII activating protease G511E (Marburg) variant and cardiovascular risk

Helen Ireland

¹Division of Cardiovascular Genetics, Department of Medicine, British Heart Foundation Laboratories, Royal Free and University College Medical School, London, UK

,

George J. Miller

²Medical Research Council Cardiovascular Group, Department of Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, London, UK

,

Karen E.Webb

¹Division of Cardiovascular Genetics, Department of Medicine, British Heart Foundation Laboratories, Royal Free and University College Medical School, London, UK

,

Jackie A. Cooper

¹Division of Cardiovascular Genetics, Department of Medicine, British Heart Foundation Laboratories, Royal Free and University College Medical School, London, UK

,

Steve E. Humphries

¹Division of Cardiovascular Genetics, Department of Medicine, British Heart Foundation Laboratories, Royal Free and University College Medical School, London, UK

› Author Affiliations

Abstract

Summary

A previous study had shown a strong relationship between a variant in factor VII activating protease (FSAP G511E) and advanced carotid atheroma. In-vitro, the variant has reduced fibrinolytic but normal pro-coagulant activity, which may constitute a prothrombotic state. The current study has addressed risk for coronary heart disease in a prospective study of cardio-vascular disorders (Northwick Park Heart Study II). An interactive effect upon risk was found between the 511E allele and elevated levels of cholesterol and triglyceride. Fibrinogen could substitute for triglyceride levels in this risk-interaction analysis. The findings support the proposal that the FSAP 511E allele exacerbates atherosclerosis or its clinical sequelae.

Keywords

Coronary heart disease - factor VII activating protease

Full Text

References

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