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DOI: 10.1160/TH04-10-0657
Medical conditions increasing the risk of chronic thromboembolic pulmonary hypertension
Grant support: This research was supported by the Austrian fellowship grant FWF P13834-MED (to IML), the österreichischer Selbsthilfeverein Lungenhochdruck and the Ludwig Boltzmann Institutes for Cardiovascular Research and Thrombosis Research.Publication History
Received
10 October 2004
Accepted after revision
28 February 2004
Publication Date:
14 December 2017 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00035024/200503/lookinside/thumbnails/10-1160-th04-10-0657-1.jpg)
Summary
Chronic thromboembolic pulmonary hypertension (CTEPH) is characterized by organized thromboemboli that obstruct the pulmonary vascular bed. Although CTEPH is a serious complication of acute symptomatic pulmonary embolism in 4% of cases, signs, symptoms and classical risk factors for venous thromboembolism are lacking. The aim of the present study was to identify medical conditions conferring an increased risk of CTEPH. We performed a case-control-study comparing 109 consecutive CTEPH patients to 187 patients with acute pulmonary embolism that was confirmed by a high probability lung scan. Splenectomy (odds ratio=13, 95% CI 2.7–127), ventriculoatrial (VA-) shunt for the treatment of hydrocephalus (odds ratio=13, 95% CI 2.5–129) and chronic inflammatory disorders, such as osteomyelitis and inflammatory bowel disease (IBD, odds ratio=67, 95% CI 7.9–8832) were associated with an increased risk of CTEPH.
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