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Thromb Haemost 2005; 93(03): 512-516
DOI: 10.1160/TH04-10-0657
Blood Coagulation, Fibrinolysis and Cellular Haemostasis
Schattauer GmbH

Medical conditions increasing the risk of chronic thromboembolic pulmonary hypertension

Diana Bonderman
1   Medical University of Vienna, Departments of Cardiology, Medical University of Vienna, Vienna, Austria
,
Johannes Jakowitsch
1   Medical University of Vienna, Departments of Cardiology, Medical University of Vienna, Vienna, Austria
,
Christopher Adlbrecht
1   Medical University of Vienna, Departments of Cardiology, Medical University of Vienna, Vienna, Austria
,
Michael Schemper
2   Department of Medical Computer Sciences; Medical University of Vienna, Vienna, Austria
,
Paul A. Kyrle
3   Department of Hematology; Medical University of Vienna, Vienna, Austria
,
Verena Schönauer
3   Department of Hematology; Medical University of Vienna, Vienna, Austria
,
Markus Exner
4   Department of Laboratory Medicine; Medical University of Vienna, Vienna, Austria
,
Walter Klepetko
5   Department of Cardiothoracic Surgery; Medical University of Vienna, Vienna, Austria
,
Meinhard P. Kneussl
6   Department of Pulmonary Medicine; Medical University of Vienna, Vienna, Austria
,
Gerald Maurer
1   Medical University of Vienna, Departments of Cardiology, Medical University of Vienna, Vienna, Austria
,
Irene Lang
1   Medical University of Vienna, Departments of Cardiology, Medical University of Vienna, Vienna, Austria
› InstitutsangabenGrant support: This research was supported by the Austrian fellowship grant FWF P13834-MED (to IML), the österreichischer Selbsthilfeverein Lungenhochdruck and the Ludwig Boltzmann Institutes for Cardiovascular Research and Thrombosis Research.
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Publikationsverlauf

Received 10. Oktober 2004

Accepted after revision 28. Februar 2004

Publikationsdatum:
14. Dezember 2017 (online)

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Summary

Chronic thromboembolic pulmonary hypertension (CTEPH) is characterized by organized thromboemboli that obstruct the pulmonary vascular bed. Although CTEPH is a serious complication of acute symptomatic pulmonary embolism in 4% of cases, signs, symptoms and classical risk factors for venous thromboembolism are lacking. The aim of the present study was to identify medical conditions conferring an increased risk of CTEPH. We performed a case-control-study comparing 109 consecutive CTEPH patients to 187 patients with acute pulmonary embolism that was confirmed by a high probability lung scan. Splenectomy (odds ratio=13, 95% CI 2.7–127), ventriculoatrial (VA-) shunt for the treatment of hydrocephalus (odds ratio=13, 95% CI 2.5–129) and chronic inflammatory disorders, such as osteomyelitis and inflammatory bowel disease (IBD, odds ratio=67, 95% CI 7.9–8832) were associated with an increased risk of CTEPH.

Keywords

Pulmonary embolism - clinical / epidemiological studies - acquired coagulation disorders - infection / bacterial - viral
 

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