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Thromb Haemost 2005; 93(03): 411-413
DOI: 10.1160/TH04-11-0715
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Schattauer GmbH

Protein Z and protein Z-dependent protease inhibitor

Determinants of levels and risk of venous thrombosis
Ali Al-Shanqeeti
1   Division of Haematology, Washington University, St. Louis, Missouri, USA
,
Astrid van Hylckama Vlieg
2   The Department of Clinical Epidemiology and Haemostasis, Leiden University Medical Center, Leiden, The Netherlands
3   Thrombosis Research Center, Leiden University Medical Center, Leiden, The Netherlands
,
Erik Berntorp
4   The Department for Coagulation Disorders, Malmo University Hospital, Sweden
,
Frits R. Rosendaal
2   The Department of Clinical Epidemiology and Haemostasis, Leiden University Medical Center, Leiden, The Netherlands
3   Thrombosis Research Center, Leiden University Medical Center, Leiden, The Netherlands
,
George J. Broze Jr.
1   Division of Haematology, Washington University, St. Louis, Missouri, USA
› InstitutsangabenFinancial support: This work was supported in part by grants from the National Institutes of Health (HL60782) and the Netherlands Heart Foundation (89.063).
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Publikationsverlauf

Received 04. November 2004

Accepted after revision 28. Februar 2004

Publikationsdatum:
14. Dezember 2017 (online)

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Summary

To assess the potential roles of protein Z (PZ) and protein Z-dependent protease inhibitor (ZPI) in venous thrombosis, their plasma levels were measured in 426 individuals with venous thrombosis and 471 control individuals participating in the Leiden Thrombophilia Study. A relationship between the level of PZ or ZPI and venous thrombosis was not detected in the overall case-control study. PZ and ZPI circulate as a complex and their plasma levels are interdependent. Both PZ and ZPI are increased with oral contraceptive use and reduced with oral anticoagulant therapy.

Keywords

Coagulation inhibitors - clinical / epidemiological studies - thrombophilia
 

  • References

  • 1 Sejima H, Hayashi T, Deyashiki Y. et al. Primary structure of vitamin K-dependent human protein Z. Biochem Biophys Res Commun 1990; 171: 661-8.
    CrossrefPubMedGoogle Scholar
  • 2 Ichinose A. et al. Amino acid sequence of human protein Z, a vitamin K-dependent plasma glycoprotein. Biochem Biophys Res Commun 1990; 172: 1139-44.
    CrossrefPubMedGoogle Scholar
  • 3 Han X, Fiehler R, Broze Jr GJ. Isolation of a protein Z-dependent plasma protease inhibitor. Proc Natl Acad Sci USA 1998; 95: 9250-5.
    CrossrefPubMedGoogle Scholar
  • 4 Han X, Huang Z-F, Fiehler R. et al. The protein Z-dependent protease inhibitor is a serpin. Biochemistry 1999; 38: 11073-8.
    CrossrefPubMedGoogle Scholar
  • 5 Han X, Fiehler R, Broze Jr GJ. Characterization of protein Z-dependent protease inhibitor. Blood 2000; 96: 3049-55.
    CrossrefPubMedGoogle Scholar
  • 6 Miletich JP, Broze Jr GJ. Human plasma protein Z antigen: range in normal subjects and the effect of warfarin therapy. Blood 1987; 69: 1580-6.
    CrossrefPubMedGoogle Scholar
  • 7 Tabatabai A, Fiehler R, Broze Jr GJ. Protein Z circulates in plasma in a complex with protein Z-dependent protease inhibitor. Thromb Haemost 2001; 85: 655-60.
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 8 Yin Z-F, Huang Z-F, Cui J. et al. Prothrombotic phenotype of protein Z deficiency. Proc Natl Acad Sci USA 2000; 97: 6734-8.
    CrossrefPubMedGoogle Scholar
  • 9 Vasse M, Guegan-Massardier E, Borg J-Y. et al. High frequency of protein Z deficiency in patients with ischemic stroke. Lancet 2001; 357: 933-4.
    CrossrefPubMedGoogle Scholar
  • 10 Kobelt K, Biasiutti FD, Mattle HP. et al. Protein Z in ischaemic stroke. Br J Haematol 2001; 114: 169-73.
    CrossrefPubMedGoogle Scholar
  • 11 Heeb MJ. et al. Low protein Z levels and risk of ischemic stroke: differences by diabetic status and gender. Blood Cells Mol Dis 2002; 29: 139-44.
    CrossrefPubMedGoogle Scholar
  • 12 Lichy C, Kropp S, Dong-Si T. et al. A common polymorphism of the protein Z gene is associated with protein Z plasma levels and with risk of cerebral ischemia in the young. Stroke 2004; 35: 40-5.
    CrossrefPubMedGoogle Scholar
  • 13 Lopaciuk S. et al. Protein Z in young survivors of ischemic stroke. Thromb Haemost 2002; 88: 436
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 14 McQuillan AM, Eikelboom JW, Hankey GJ. et al. Protein Z in ischemic stroke and its etiologic subtypes. Stroke 2003; 34: 2415-9.
    CrossrefPubMedGoogle Scholar
  • 15 Santacroce R, Cappucci F, Di Perna P. et al. Protein Z gene polymorphisms are associated with protein Z plasma levels. J Thromb Haemost 2004; 2: 1197-9.
    CrossrefPubMedGoogle Scholar
  • 16 Fedi S. et al. Low protein Z plasma levels are independently associated with acute coronary syndromes. Thromb Haemost 2003; 90: 1173-8.
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 17 Gris J-C, Quere I, Dechaud H. et al. High frequency of protein Z deficiency in patients with unexplained early fetal loss. Blood 2002; 99: 2606-8.
    CrossrefPubMedGoogle Scholar
  • 18 Steffano B, Forastiero R. et al. Low plasma protein Z levels in patients with antiphospholipid antibodies. Blood Coagul Fibrinolysis 2001; 12: 411-2.
    CrossrefPubMedGoogle Scholar
  • 19 McColl MD, Deans A, Maclean P. et al. Plasma protein Z deficiency is common in women with antiphospholipid antibodies. Br J Haematol 2003; 120: 907-15.
    CrossrefPubMedGoogle Scholar
  • 20 Forastiero RR, Matinuzzo ME. et al. Autoimmune antiphospholipid antibodies impair the inhibition of activated factor X by protein Z/protein Z-dependent protease inhibitor. J Thromb Haemost 2003; 1: 1764-70.
    CrossrefPubMedGoogle Scholar
  • 21 Rice I G, Futers TS, Grant PJ. Identification of novel polymorphisms within the protein Z gene, haplotype distribution and linkage analysis. Thromb Haemost 2001; 85: 1123-4.
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 22 van der Meer FJM, Koster T, Vandenbroucke JP. et al. The Leiden Thrombophilia Study (LETS). Thromb Haemost 1997; 78: 631-5.
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 23 Jerkeman A. et al. Correlation between different intensities of anti-vitamin K treatment and coagulation parameters. Thromb Res 2000; 98: 467-71.
    CrossrefPubMedGoogle Scholar
  • 24 Kemkes-Matthes B. et al. Protein Z influences the prothrombotic phenotype of factor V Leiden in humans. Thromb Res 2002; 106: 183-5.
    CrossrefPubMedGoogle Scholar
  • 25 Cui J, Eitzman DT, Westrick RJ. et al. Spontaneous thrombosis in mice carrying the factor V Leiden mutation. Blood 2000; 96: 4222-6.
    PubMedGoogle Scholar