Thromb Haemost 2005; 93(03): 411-413
DOI: 10.1160/TH04-11-0715
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Protein Z and protein Z-dependent protease inhibitor

Determinants of levels and risk of venous thrombosis
Ali Al-Shanqeeti
1   Division of Haematology, Washington University, St. Louis, Missouri, USA
,
Astrid van Hylckama Vlieg
2   The Department of Clinical Epidemiology and Haemostasis, Leiden University Medical Center, Leiden, The Netherlands
3   Thrombosis Research Center, Leiden University Medical Center, Leiden, The Netherlands
,
Erik Berntorp
4   The Department for Coagulation Disorders, Malmo University Hospital, Sweden
,
Frits R. Rosendaal
2   The Department of Clinical Epidemiology and Haemostasis, Leiden University Medical Center, Leiden, The Netherlands
3   Thrombosis Research Center, Leiden University Medical Center, Leiden, The Netherlands
,
George J. Broze Jr.
1   Division of Haematology, Washington University, St. Louis, Missouri, USA
› Institutsangaben
Financial support: This work was supported in part by grants from the National Institutes of Health (HL60782) and the Netherlands Heart Foundation (89.063).
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Publikationsverlauf

Received 04. November 2004

Accepted after revision 28. Februar 2004

Publikationsdatum:
14. Dezember 2017 (online)

Summary

To assess the potential roles of protein Z (PZ) and protein Z-dependent protease inhibitor (ZPI) in venous thrombosis, their plasma levels were measured in 426 individuals with venous thrombosis and 471 control individuals participating in the Leiden Thrombophilia Study. A relationship between the level of PZ or ZPI and venous thrombosis was not detected in the overall case-control study. PZ and ZPI circulate as a complex and their plasma levels are interdependent. Both PZ and ZPI are increased with oral contraceptive use and reduced with oral anticoagulant therapy.

 
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