Migration of dendritic cells across blood and lymphatic endothelial barriers

Annalisa Del Prete; Massimo Locati; Karel Otero; Elena Riboldi; Alberto Mantovani; Annunciata Vecchi; Silvano Sozzani

doi:10.1160/TH05-10-0974

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2006; 95(01): 22-28
DOI: 10.1160/TH05-10-0974

Theme Issue Article

Schattauer GmbH

Migration of dendritic cells across blood and lymphatic endothelial barriers

Annalisa Del Prete

¹Section of Clinical Biochemistry, University of Bari, Bari, Italy

,

Massimo Locati

²Institute of General Pathology, University of Milan, Milan, Italy

³Istituto Clinico Humanitas, Rozzano, Italy

,

Karel Otero

³Istituto Clinico Humanitas, Rozzano, Italy

,

Elena Riboldi

⁴Section of General Pathology and Immunology, University of Brescia, Brescia, Italy

,

Alberto Mantovani

²Institute of General Pathology, University of Milan, Milan, Italy

³Istituto Clinico Humanitas, Rozzano, Italy

,

Annunciata Vecchi

³Istituto Clinico Humanitas, Rozzano, Italy

,

Silvano Sozzani

⁴Section of General Pathology and Immunology, University of Brescia, Brescia, Italy

› Author Affiliations

Abstract

Summary

Dendritic cells (DC) are professional antigen presenting cells which playa pivotal role in the activation of adaptive immunity. Tissue invasion by pathogens induces the recruitment of blood DC to the site of infection and contributes to their subsequent migration to secondary lymphoid organs. This complex process relies on the expression and regulation of receptors for chemotactic factors on the surface of migrating DC and on the activation of adhesion molecules which allow DC to properly interact with both blood and lymphatic vessels. In the absence of correct tissue localization, DC fail to promote proper immune responses. Therefore, the interaction of DC with endothelial cells represents a fundamental step for DC biology.

Keywords

Dendritic cells - chemokines - endothelial cells - adhesion molecules - signal transduction

Full Text

References

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