Fibrinolysis and host response in bacterial infections

Simone Bergmann; Sven Hammerschmidt

doi:10.1160/TH07-02-0117

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2007; 98(03): 512-520
DOI: 10.1160/TH07-02-0117

Theme Issue Article

Schattauer GmbH

Fibrinolysis and host response in bacterial infections

Simone Bergmann

¹Max von Pettenkofer Institute, Ludwig-Maximilians-University of Munich, Munich, Germany

,

Sven Hammerschmidt

¹Max von Pettenkofer Institute, Ludwig-Maximilians-University of Munich, Munich, Germany

› Author Affiliations

Abstract

Summary

The plasminogen activation system is part of the fibrinolysis which is tightly regulated and protected against dysfunction by various activators and inhibitors. However, microorganisms including bacteria, fungi and also parasites have been proven to interact in a specific manner with components of the fibrinolytic pathways. Pathogenic bacteria are capable to subvert the function of proteases, activators or inhibitors for their own benefits including dissemination within the host and evasion of host inflammatory immune response. Here, we provide a state of the art overview of the divers strategies employed by bacteria to interact with components of the fibrinolytic system and to exploit the system for invasion. Moreover, the role of factors of the fibrinolytic cascade in inflammatory host response due to different bacterial infections will be presented.

Keywords

Plasminogen - inflammation - urokinase/receptor - plasminogen activator inhibitor - bacterial infection

Full Text

References

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