Thromb Haemost 2008; 99(02): 249
DOI: 10.1160/TH08-01-0010
Editorial Focus
Schattauer GmbH

Platelets play a direct role in sepsis-associated endothelial cell death

John W. Semple
1   Toronto Platelet Immunobiology Group, St. Michael's Hospital, Toronto, Ontario, Canada
› Author Affiliations
Further Information

Publication History

Received: 08 January 2008

Accepted after major revision: 08 January 2007

Publication Date:
24 November 2017 (online)

 

 
  • References

  • 1 Aslam R, Speck ER, Kim M. et al. et al. Platelet Toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumor necrosis factor-production in vivo. Blood 2006; 107: 637-641.
  • 2 Clark SR, Ma AC, Tavener SA. et al. Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood. Nature Med 2007; 13: 463-469.
  • 3 Semple JW, Aslam R, Kim M. et al. Platelet-bound lipopolysaccharide enhances Fc receptor-mediated phagocytosis of IgG opsonized platelets. Blood 2007; 109: 4803-4805.
  • 4 Kuckleburg CJ, Tiwari R, Czuprynski CJ. Endothelial cell apoptosis induced by bacteria-activated platelets requires caspase-8 and –9 and generation of reactive oxygen species. Thromb Haemost 2008; 99: 363-372.