PDF herunterladen
Thromb Haemost 2009; 101(03): 417-418
DOI: 10.1160/TH09-01-0067
Editorial Focus
Schattauer GmbH

Understanding low INR in clinical practice

Elaine M. Hylek
1   Department of Medicine, Research Unit-Section of General Internal Medicine, Boston University School of Medicine, Boston, Massachussetts, USA
,
Adam J. Rose
1   Department of Medicine, Research Unit-Section of General Internal Medicine, Boston University School of Medicine, Boston, Massachussetts, USA
2   Center for Health Quality, Outcomes, and Economic Research, Bedford VA Medical Center, Bedford, Massachussetts, USA
› InstitutsangabenFinancial support: Dr. Hylek reports receiving grant support from AstraZeneca, serving as an advisor to Boehringer Ingelheim, Bristol-Myers Squibb, Sanofi-Aventis, and The Medicines Company; and participating in clinical symposia sponsored by Bayer and Bristol-Myers Squibb. Dr. Rose is supported by a career development award from the United States Department of Veterans Affairs, Health Services Research and Development Service. The opinions expressed in this commentary are those of the authors and do not represent the official views of the Department of Veterans Affairs.
Weitere Informationen

Publikationsverlauf

Received: 30. Januar 2009

Accepted: 02. Februar 2009

Publikationsdatum:
24. November 2017 (online)

Auch verfügbar auf
    Lizenzen und Reprints

 

 

  • References

  • 1 Spranca M, Minsk E, Baron J. Omission and comission in judgement and choice. J Exp Soc Psychol 1991; 27: 76-105.
    CrossrefPubMedSuche in Google Scholar
  • 2 Hayward RA, Asch SM, Hogan MM. et al. Sins of omission: getting too little medical care may be the greatest threat to patient safety. J Gen Intern Med 2005; 20: 686-691.
    CrossrefPubMedSuche in Google Scholar
  • 3 Beyth RJ, Quinn LM, Landefeld CS. Prospective evaluation of an index for predicting the risk of major bleeding in outpatients treated with warfarin. Am J Med 1998; 105: 91-99.
    CrossrefPubMedSuche in Google Scholar
  • 4 Fihn SD, Callahan CM, Martin DC. et al. The risk for and severity of bleeding complications in elderly patients treated with warfarin. The National Consortium of Anticoagulation Clinics. Ann Intern Med 1996; 124: 970-979.
    CrossrefPubMedSuche in Google Scholar
  • 5 Gage BF, Yan Y, Milligan PE. et al. Clinical classification schemes for predicting hemorrhage: results from the National Registry of Atrial Fibrillation (NRAF). Am Heart J 2006; 151: 713-719.
    CrossrefPubMedSuche in Google Scholar
  • 6 Schulman S, Beyth RJ, Kearon C. et al. Hemorrhagic complications of anticoagulant and thrombolytic treatment: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 2008; 133: 257S-298S.
    CrossrefPubMedSuche in Google Scholar
  • 7 DiMarco JP, Flaker G, Waldo AL. et al. Factors affecting bleeding risk during anticoagulant therapy in patients with atrial fibrillation: observations from the Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) study. Am Heart J 2005; 149: 650-656.
    CrossrefPubMedSuche in Google Scholar
  • 8 Choudhry NK, Soumerai SB, Normand SL. et al. Warfarin prescribing in atrial fibrillation: the impact of physician, patient, and hospital characteristics. Am J Med 2006; 119: 607-615.
    CrossrefPubMedSuche in Google Scholar
  • 9 Go AS, Hylek EM, Chang Y. et al. Anticoagulation therapy for stroke prevention in atrial fibrillation: how well do randomized trials translate into clinical practice?. J Am Med Assoc 2003; 290: 2685-2692.
    CrossrefPubMedSuche in Google Scholar
  • 10 Palareti G, Leali N, Coccheri S. et al. Bleeding complications of oral anticoagulant treatment: an inception-cohort, prospective collaborative study (ISCOAT). Italian Study on Complications of Oral Anticoagulant Therapy. Lancet 1996; 348: 423-428.
    CrossrefPubMedSuche in Google Scholar
  • 11 Jones M, McEwan P, Morgan CL. et al. Evaluation of the pattern of treatment, level of anticoagulation control, and outcome of treatment with warfarin in patients with non-valvar atrial fibrillation: a record linkage study in a large British population. Heart 2005; 91: 472-477.
    CrossrefPubMedSuche in Google Scholar
  • 12 Menzin J, Boulanger L, Hauch O. et al. Quality of anticoagulation control and costs of monitoring warfarin therapy among patients with atrial fibrillation in clinic settings: a multi-site managed-care study. Ann Pharmacother 2005; 39: 446-451.
    CrossrefPubMedSuche in Google Scholar
  • 13 McCormick D, Gurwitz JH, Goldberg RJ. et al. Prevalence and quality of warfarin use for patients with atrial fibrillation in the long-term care setting. Arch Intern Med 2001; 161: 2458-2463.
    CrossrefPubMedSuche in Google Scholar
  • 14 Matchar DB, Samsa GP, Cohen SJ. et al. Improving the quality of anticoagulation of patients with atrial fibrillation in managed care organizations: results of the managing anticoagulation services trial. Am J Med 2002; 113: 42-51.
    CrossrefPubMedSuche in Google Scholar
  • 15 Kucher N, Connolly S, Beckman JA. et al. International normalized ratio increase before warfarin-associated hemorrhage: brief and subtle. Arch Intern Med 2004; 164: 2176-2179.
    CrossrefPubMedSuche in Google Scholar
  • 16 Garcia DA, Regan S, Henault LE. et al. Risk of thromboembolism with short-term interruption of warfarin therapy. Arch Intern Med 2008; 168: 63-69.
    CrossrefPubMedSuche in Google Scholar
  • 17 Hylek EM, Go AS, Chang Y. et al. Effect of intensity of oral anticoagulation on stroke severity and mortality in atrial fibrillation. New Engl J Med 2003; 349: 1019-1026.
    CrossrefPubMedSuche in Google Scholar
  • 18 Rombouts E, Rosendaal FR, Van der Meer FJ. Subtherapeutic oral anticoagulant therapy: Frequency and risk factors. Thromb Haemost 2009; 101: 552-556.
    Thieme ConnectPubMedSuche in Google Scholar
  • 19 Fihn SD, Gadisseur AA, Pasterkamp E. et al. Comparison of control and stability of oral anticoagulant therapy using acenocoumarol versus phenprocoumon. Thromb Haemost 2003; 90: 260-266.
    Thieme ConnectPubMedSuche in Google Scholar
  • 20 van Geest-Daalderop JH, Hutten BA, Péquériaux NC. et al. The influence on INRs and coagulation factors of the time span between blood sample collection and intake of phenprocoumon or acenocoumarol: consequences for the assessment of the dose. Thromb Haemost 2007; 98: 738-746.
    Thieme ConnectPubMedSuche in Google Scholar
  • 21 Beinema M, Brouwers JR, Schalekamp T, Wilffert B. Pharmacogenetic differences between warfarin, acenocoumarol and phenprocoumon. Thromb Haemost 2008; 100: 1052-1057.
    Thieme ConnectPubMedSuche in Google Scholar
  • 22 van der Meer FJ, Rosendaal FR, Vandenbroucke JP, Briët E. Bleeding complications in oral anticoagulant therapy.. An analysis of risk factors. Arch Intern Med 1993; 153: 1557-1562.
    CrossrefPubMedSuche in Google Scholar
  • 23 Gadisseur AP, van der Meer FJ, Adriaansen HJ. et al. Therapeutic quality control of oral anticoagulant therapy comparing the short-acting acenocoumarol and the long-acting phenprocoumon. Br J Haematol 2002; 117: 940-946.
    CrossrefPubMedSuche in Google Scholar
  • 24 Visser LE, van Schaik RH, van Vliet M. et al. The risk of bleeding complications in patients with cytochrome P450 CYP2C9*2 or CYP2C9*3 alleles on acenocoumarol or phenprocoumon. Thromb Haemost 2004; 92: 61-66.
    Thieme ConnectPubMedSuche in Google Scholar