Rivaroxaban and false positive lupus anticoagulant testing

Thromb Haemost 2011; 105(02): 385-386
DOI: 10.1160/TH10-08-0511

Letters to the Editor

Schattauer GmbH

Eileen Merriman

¹Department of Haematology, Monash Medical Centre, Clayton, Victoria, Australia

,

Zane Kaplan

¹Department of Haematology, Monash Medical Centre, Clayton, Victoria, Australia

,

Jenny Butler

²Haematology Laboratory, Monash Medical Centre, Clayton, Victoria, Australia

,

Erica Malan

²Haematology Laboratory, Monash Medical Centre, Clayton, Victoria, Australia

,

Eng Gan

²Haematology Laboratory, Monash Medical Centre, Clayton, Victoria, Australia

,

Huyen Tran

¹Department of Haematology, Monash Medical Centre, Clayton, Victoria, Australia

³Australian Centre for Blood Diseases, Prahran, Victoria, Australia

References
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2 Greaves M, Cohen H, MacHin SJ. et al. Guidelines on the investigation and management of the anti-phospholipid syndrome. Br J Haematol 2000; 109: 704-715.
3 Tripodi A. Testing for lupus anticoagulants: all that a clinician should know. Lupus 2009; 18: 291-298.
4 Genzen JR, Miller JL. Presence of direct thrombin inhibitors can affect the results and interpretation of lupus anticoagulant testing. Am J Clin Pathol 2005; 124: 586-593.
5 Gosselin RC, King JH, Janatpur KA. et al. Effects of pentasaccharide (fondaparinux) and direct thrombin inhibitors on coagulation testing. Arch Pathol Lab Med 2004; 128: 1142-1145.
6 Lambert M, Ferrard-Sasson G, Dubucquoi S. et al. Diluted Russell viper-venom time improves identification of antiphospholipid syndrome in a lupus anticoagulant-positive patient population. Thromb Haemost 2009; 101: 577-581.
7 Samama MM, Martinoli JL, LeFlem L. et al. Assessment of laboratory assays to measure rivaroxaban – an oral, direct factor Xa inhibitor. Thromb Haemost 2010; 103: 815-825.