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Thromb Haemost 2013; 110(05): 920-924
DOI: 10.1160/TH13-03-0183
Theme Issue Article
Schattauer GmbH

Protein degradation systems in platelets

Bjoern F. Kraemer
1   Medizinische Klinik und Poliklinik I, Klinikum der Universität München, München, Germany
,
Andrew S. Weyrich
2   Molecular Medicine Program and the Departments of Internal Medicine, University of Utah, Salt Lake City, Utah, USA
,
Stephan Lindemann
3   Medizinische Klinik und Poliklinik III, Universitätsklinikum Tübingen, Tübingen, Germany
› Author Affiliations
Further Information

Publication History

Received: 01 March 2013

Accepted after major revision: 28 July 2013

Publication Date:
01 December 2017 (online)

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Summary

Protein synthesis and degradation are essential processes that allow cells to survive and adapt to their surrounding milieu. In nucleated cells, the degradation and/or cleavage of proteins is required to eliminate aberrant proteins. Cells also degrade proteins as a mechanism for cell signalling and complex cellular functions. Although the last decade has convincingly shown that platelets synthesise proteins, the roles of protein degradation in these anucleate cytoplasts are less clear. Here we review what is known about protein degradation in platelets placing particular emphasis on the proteasome and the cysteine protease calpain.

Keywords

Platelets - protein degradation - proteasome - calpain
 

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