Protein degradation systems in platelets

Bjoern F. Kraemer; Andrew S. Weyrich; Stephan Lindemann

doi:10.1160/TH13-03-0183

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2013; 110(05): 920-924
DOI: 10.1160/TH13-03-0183

Theme Issue Article

Schattauer GmbH

Protein degradation systems in platelets

Authors

Bjoern F. Kraemer

¹Medizinische Klinik und Poliklinik I, Klinikum der Universität München, München, Germany
Andrew S. Weyrich

²Molecular Medicine Program and the Departments of Internal Medicine, University of Utah, Salt Lake City, Utah, USA
Stephan Lindemann

³Medizinische Klinik und Poliklinik III, Universitätsklinikum Tübingen, Tübingen, Germany

Abstract

Summary

Protein synthesis and degradation are essential processes that allow cells to survive and adapt to their surrounding milieu. In nucleated cells, the degradation and/or cleavage of proteins is required to eliminate aberrant proteins. Cells also degrade proteins as a mechanism for cell signalling and complex cellular functions. Although the last decade has convincingly shown that platelets synthesise proteins, the roles of protein degradation in these anucleate cytoplasts are less clear. Here we review what is known about protein degradation in platelets placing particular emphasis on the proteasome and the cysteine protease calpain.

Keywords

Platelets - protein degradation - proteasome - calpain

Full Text

References

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