Klinische Studien zu neuen direkten oralen Antikoagulanzien

J. Harenberg; C. Weiss; S. Marx; S. Zolfaghari

doi:10.12687/phleb2146-3-2013

Phlebologie, Inhaltsverzeichnis

Phlebologie 2013; 42(03): 139-148
DOI: 10.12687/phleb2146-3-2013

Originalarbeit

Schattauer GmbH

Clinical trials with new direct oral anticoagulants

Additive value of indirect comparisons (network meta-analyses) Artikel in mehreren Sprachen: deutsch | English

Authors

J. Harenberg

¹Abteilung für klinische Pharmakologie, Medizinische Fakultät Mannheim, Universität Heidelberg, Mannheim, Deutschland
C. Weiss

²Abteilung für Biometrie und Statistik, Medizinische Fakultät Mannheim, Universität Heidelberg, Mannheim, Deutschland
S. Marx

¹Abteilung für klinische Pharmakologie, Medizinische Fakultät Mannheim, Universität Heidelberg, Mannheim, Deutschland
S. Zolfaghari

¹Abteilung für klinische Pharmakologie, Medizinische Fakultät Mannheim, Universität Heidelberg, Mannheim, Deutschland

Abstract

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Summary

To compare the efficacy and safety of the new direct oral anticoagulants (DOAC), ideally head-to-head clinical trials should be performed. Given the expense of such an undertaking, it is highly unlikely that such a comparison would be performed. Therefore, there is a need for an unbiased comparative assessment of the benefits and risks of the DOACs, based on the available trial data. Indirect or mixed treatment comparisons may be an useful tool to overcome these limitations also known as network meta-analysis (NMA).

The aim of this paper is to give an overview on published NMAs for dabigatran, rivaroxaban and apixaban, each assessed against warfarin in patients with atrial fibrillation, and against enoxaparin in patients undergoing total knee and total hip replacement surgery, in order to obtain insights into the comparability of the adopted methodological techniques.

English version available at:www.phlebologieonline.de

Keywords

Oral anticoagulants - Apixaban - Dabigatran - Rivaroxaban - Edoxaban - atrial fibrillation - total knee replace ment - total hip replacement - pro phylaxis of thromboembolism

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Referenzen

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