Summary
An eight-month-old mixed-breed dog was presented with a history of sudden onset pelvic
limb lameness. Radiographic and computed tomographic examinations demonstrated an
osteolytic process involving the lumbar spine and pelvis. A comprehensive work-up
including serial radiographic skeletal survey, biopsy, routine laboratory investigation
and evaluation of parathyroid hormone (PTH) and 25-hydroxy-vitamin D levels failed
to reveal any underlying cause for the osteolysis. Conservative treatment using the
bisphosphonate drug alendronate and oral analgesic medications resulted in a return
to nearly normal long-term function, despite massive lumbar and pelvic osteolysis.
The clinical, radiological and histopathological features in this dog are reported,
and similarities with the human condition known as Gorham’s disease are discussed.
Keywords
Osteolysis - Gorham’s disease - dog - idiopathic