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CC BY-NC-ND 4.0 · South Asian J Cancer 2017; 06(02): 081-083
DOI: 10.4103/2278-330X.208851
ORIGINAL ARTICLE : SAARC Selection

Impact and prognostic value of 18F-fluorodeoxyglucose positron emission tomography-computed tomography scan in the evaluation of residual head and neck cancer: Single-center experience from Pakistan

Saima Riaz
Department of Nuclear Medicine, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore
,
Humayun Bashir
Department of Nuclear Medicine, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore
,
Hassan Iqbal
Department of Surgical Oncology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore
,
Arif Jamshed
Department of Radiation Oncology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore
,
Ahmad Murtaza
Department of Radiology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore
,
Raza Hussain
Department of Surgical Oncology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore
› Institutsangaben Source of Support: Nill.
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Abstract

Background: Overview of clinical impact of positron emission tomography-computed tomography (PET-CT) scans in patients with head and neck carcinomas at our center. Methods: Retrospective review of posttreatment 18F-fluorodeoxyglucose (18F-FDG) PET-CT scans in patients with head and neck carcinomas with risk of residual disease. Clinical outcome served as the reference standard. Results: This study included 93 patients (65.6% males, mean age: 48.8 years ± 17.2 standard deviation) with squamous cell carcinoma as most frequent histopathology (91.4%). PET-CT scans were performed on average 6 months posttreatment. Diagnostic accuracy, positive predictive value, and negative predictive value of PET-CT for disease were found to be 88%, 88%, and 92%, respectively. A median follow-up of 24 months was available for 91 patients. Kaplan–Meier curves showed significantly higher disease-free survival with negative PET-CT as compared to positive PET-CT (P = 0.01) and maximum standardized uptake values of <5.0 (P = 0.01). Conclusion: FDG PET-CT has diagnostic and prognostic implications in treated patient of head and neck cancers.

Key words

18F-fluorodeoxyglucose positron emission tomography-computed tomography scan - disease-free survival - head and neck cancer - maximum standardized uptake values - squamous cell carcinoma


Publikationsverlauf

Artikel online veröffentlicht:
22. Dezember 2020

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  • References

  • 1 Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin 2011;61:69-90.
  • 2 Abraham J. Imaging for head and neck cancer. Surg Oncol Clin N Am 2015;24:455-71.
  • 3 Castaldi P, Leccisotti L, Bussu F, Miccichè F, Rufini V. Role of (18) F-FDG PET-CT in head and neck squamous cell carcinoma. Acta Otorhinolaryngol Ital 2013;33:1-8.
  • 4 Sanderson RJ, Ironside JA. Squamous cell carcinomas of the head and neck. BMJ 2002;325:822-7.
  • 5 Gupta T, Master Z, Kannan S, Agarwal JP, Ghsoh-Laskar S, Rangarajan V, et al. Diagnostic performance of post-treatment FDG PET or FDG PET/CT imaging in head and neck cancer: A systematic review and meta-analysis. Eur J Nucl Med Mol Imaging 2011;38:2083-95.
  • 6 Ware RE, Matthews JP, Hicks RJ, Porceddu S, Hogg A, Rischin D, et al. Usefulness of fluorine-18 fluorodeoxyglucose positron emission tomography in patients with a residual structural abnormality after definitive treatment for squamous cell carcinoma of the head and neck. Head Neck 2004;26:1008-17.
  • 7 Porceddu SV, Pryor DI, Burmeister E, Burmeister BH, Poulsen MG, Foote MC, et al. Results of a prospective study of positron emission tomography-directed management of residual nodal abnormalities in node-positive head and neck cancer after definitive radiotherapy with or without systemic therapy. Head Neck 2011;33:1675-82.
  • 8 Ito K, Shimoji K, Miyata Y, Kamiya K, Minamimoto R, Kubota K, et al. Prognostic value of post-treatment (18) F-FDG PET/CT for advanced head and neck cancer after combined intra-arterial chemotherapy and radiotherapy. Chin J Cancer Res 2014;26:30-7.
  • 9 Torizuka T, Tanizaki Y, Kanno T, Futatsubashi M, Naitou K, Ueda Y, et al. Prognostic value of 18F-FDG PET in patients with head and neck squamous cell cancer. AJR Am J Roentgenol 2009;192:W156-60.