CC BY-NC-ND 4.0 · Asian J Neurosurg 2021; 16(01): 8-13
DOI: 10.4103/ajns.AJNS_265_20
Narrative Review Article

Are thinking machines breaking new frontiers in neuro-oncology? A narrative review on the emerging role of machine learning in neuro-oncological practice

Mustafa Hussain
1   Department of Neurosurgery, Aga Khan University Hospital, Karachi
,
Ainsia Shabbir
2   Department of Computer and Information Systems Engineering, NED University of Engineering and Technology, Karachi
,
Saqib Bakhshi
1   Department of Neurosurgery, Aga Khan University Hospital, Karachi
,
Muhammad Shamim
1   Department of Neurosurgery, Aga Khan University Hospital, Karachi
› Author Affiliations

Medical science in general and oncology in particular are dynamic, rapidly evolving subjects. Brain and spine tumors, whether primary or secondary, constitute a significant number of cases in any oncological practice. With the rapid influx of data in all aspects of neuro-oncological care, it is almost impossible for practicing clinicians to remain abreast with the current trends, or to synthesize the available data for it to be maximally beneficial for their patients. Machine-learning (ML) tools are fast gaining acceptance as an alternative to conventional reliance on online data. ML uses artificial intelligence to provide a computer algorithm-based information to clinicians. Different ML models have been proposed in the literature with a variable degree of precision and database requirements. ML can potentially solve the aforementioned problems for practicing clinicians by not just extracting and analyzing useful data, by minimizing or eliminating certain potential areas of human error, by creating patient-specific treatment plans, and also by predicting outcomes with reasonable accuracy. Current information on ML in neuro-oncology is scattered, and this literature review is an attempt to consolidate it and provide recent updates.

Financial support and sponsorship

Nil.




Publication History

Received: 29 May 2020

Accepted: 17 September 2020

Article published online:
16 August 2022

© 2021. Asian Congress of Neurological Surgeons. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 
  • References

  • 1 Bibault JE, Giraud P, Burgun A. Big Data and machine learning in radiation oncology: State of the art and future prospects. Cancer Lett 2016;382:110-7.
  • 2 Bzdok D, Altman N, Krzywinski M. Points of Significance: Statistics versus Machine Learning. Nature Publishing Group; 2018.
  • 3 Rebala G, Ravi A, Churiwala S. Machine Learning Definition and Basics. InAn Introduction to Machine Learning 2019 (pp. 1-17). Springer, Cham.
  • 4 George DN, Jehlol HB, Oleiwi AS. Brain tumor detection using shape features and machine learning algorithms. Int J Adv Res Comp Sci Software Eng 2015;5:454-9.
  • 5 Lowd D, Domingos P, editors. Naive Bayes Models for Probability Estimation. Proceedings of the 22nd International Conference on Machine Learning; 2005.
  • 6 Land WH, Schaffer JD. The Support Vector Machine. In The Art and Science of Machine Intelligence 2020 (pp. 45-76). Springer, Cham.
  • 7 Senders JT, Zaki MM, Karhade AV, Chang B, Gormley WB, Broekman ML, et al. An introduction and overview of machine learning in neurosurgical care. Acta Neurochir (Wien) 2018;160:29-38.
  • 8 Ebrahimi Zade A, Shahabi Haghighi S, Soltani M. Reinforcement learning for optimal scheduling of Glioblastoma treatment with Temozolomide. Comput Methods Programs Biomed 2020;193:105443.
  • 9 Sharma V, Rai S, Dev A. A comprehensive study of artificial neural networks. International Journal of Advanced research in computer science and software engineering. 2012 Oct;2(10).
  • 10 Ravì D, Wong C, Deligianni F, Berthelot M, Andreu-Perez J, Lo B, Yang GZ. Deep learning for health informatics. IEEE journal of biomedical and health informatics. 2016 Dec 29;21:4-21.
  • 11 Sakib S, Ahmed N, Kabir AJ, Ahmed H. An Overview of Convolutional Neural Network: Its Architecture and Applications; 2019.
  • 12 Caulo M, Panara V, Tortora D, Mattei PA, Briganti C, Pravatà E, et al. Data-driven grading of brain gliomas: A multiparametric MR imaging study. Radiology 2014;272:494-503.
  • 13 Jensen JH, Helpern JA, Ramani A, Lu H, Kaczynski K. Diffusional kurtosis imaging: The quantification of non-Gaussian water diffusion by means of magnetic resonance imaging. Magnetic resonance in medicine: An Off J Int Soc Magnetic Res Med 2005;53:1432-40.
  • 14 Takahashi S, Takahashi W, Tanaka S, Haga A, Nakamoto T, Suzuki Y, et al. Radiomics analysis for glioma malignancy evaluation using diffusion kurtosis and tensor imaging. Int J Radiat Oncol Biol Phys 2019;105:784-91.
  • 15 Peeken JC, Goldberg T, Pyka T, Bernhofer M, Wiestler B, Kessel KA, et al. Combining multimodal imaging and treatment features improves machine learning-based prognostic assessment in patients with glioblastoma multiforme. Cancer Med 2019;8:128-36.
  • 16 Papp L, Pötsch N, Grahovac M, Schmidbauer V, Woehrer A, Preusser M, et al. Glioma survival prediction with combined analysis of in vivo 11 C-MET PET features, ex vivo features, and patient features by supervised machine learning. J Nucl Med 2018;59:892-9.
  • 17 Zacharaki EI, Morita N, Bhatt P, O'Rourke DM, Melhem ER, Davatzikos C. Survival analysis of patients with high-grade gliomas based on data mining of imaging variables. AJNR Am J Neuroradiol 2012;33:1065-71.
  • 18 Pillai JJ, Zacá D. Clinical utility of cerebrovascular reactivity mapping in patients with low grade gliomas. World J Clin Oncol 2011;2:397-403.
  • 19 Nie D, Zhang H, Adeli E, Liu L, Shen D, editors. 3D Deep Learning for Multi-Modal Imaging-Guided Survival time Prediction of Brain Tumor Patients. International Conference on Medical Image Computing and Computer-Assisted Intervention. Springer; 2016.
  • 20 Hollon TC, Parikh A, Pandian B, Tarpeh J, Orringer DA, Barkan AL, et al. A machine learning approach to predict early outcomes after pituitary adenoma surgery. Neurosurg Focus 2018;45:E8.
  • 21 Cha YJ, Jang WI, Kim MS, Yoo HJ, Paik EK, Jeong HK, et al. Prediction of response to stereotactic radiosurgery for brain metastases using convolutional neural networks. Anticancer Res 2018;38:5437-45.
  • 22 Takada M, Sugimoto M, Masuda N, Iwata H, Kuroi K, Yamashiro H, et al. Prediction of postoperative disease-free survival and brain metastasis for HER2-positive breast cancer patients treated with neoadjuvant chemotherapy plus trastuzumab using a machine learning algorithm. Breast Cancer Res Treat 2018;172:611-8.
  • 23 Witzel I, Oliveira-Ferrer L, Pantel K, Müller V, Wikman H. Breast cancer brain metastases: Biology and new clinical perspectives. Breast Cancer Res 2016;18:8.
  • 24 Blumenthal DT, Artzi M, Liberman G, Bokstein F, Aizenstein O, Ben Bashat D. Classification of high-grade glioma into tumor and Nontumor components using support vector machine. AJNR Am J Neuroradiol 2017;38:908-14.
  • 25 Rudin C. Stop explaining black box machine learning models for high stakes decisions and use interpretable models instead. Nature Mach Intelligence 2019;1:206-15.
  • 26 Bathaee Y. The artificial intelligence black box and the failure of intent and causation. Harv JL Tech 2017;31:889.
  • 27 Zeiler MD, Fergus R. Visualizing and understanding convolutional networks. InEuropean conference on computer vision 2014 Sep 6 (pp. 818-833). Springer, Cham.
  • 28 AlBadawy EA, Saha A, Mazurowski MA. Deep learning for segmentation of brain tumors: Impact of cross-institutional training and testing. Med Phys 2018;45:1150-8.
  • 29 Jarrett D, Stride E, Vallis K, Gooding MJ. Applications and limitations of machine learning in radiation oncology. The British journal of radiology. 2019 Aug;92(1100):20190001.