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CC BY-NC-ND 4.0 · Asian J Neurosurg 2021; 16(01): 62-66
DOI: 10.4103/ajns.AJNS_386_20
Original Article

Pituitary hormonal status after endoscopic endonasal transphenoidal removal of nonfunctioning pituitary adenoma: 5 years' experience in a single center

Pungjai Keandoungchun
5   Department of Internal Medicine, Prasat Neurological Institute, Bangkok
,
Wuttipong Tirakotai
1   Department of Neurosurgery, Prasat Neurological Institute, Bangkok
,
Ampai Phinthusophon
5   Department of Internal Medicine, Prasat Neurological Institute, Bangkok
,
Yodkhwan Wattanasen
2   Department of Radiology, Prasat Neurological Institute, Bangkok
,
Patcharapim Masayaanon
3   Department of Neuro-Opthalmology, Prasat Neurological Institute, Bangkok
,
Sudasawan Takathaweephon
4   Department of Nursing, Prasat Neurological Institute, Bangkok
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Background: This study focuses on hormonal disorder and medical complications postoperative endoscopic endonasal transsphenoidal approach of nonfunctioning adenoma at Prasat Neurological Institute, Bangkok, between January 2013 and December 2017. Methods and Material: Baseline characteristics, clinical complications, and hormonal status data were collected from the patients' medical records and analyzed using the descriptive statistics. Results: There were four surgeons who operated 126 cases, 17 of them were reoperation. The average age of the patients was 49 years old. The average length of stay was 13 days, and average operating time was 134 min. Visual field defect was the most common presenting symptom. Almost all the tumors were classified as pituitary macroadenoma which invaded one or two sellar walls. Total or near total tumor removal was the most extend of resection. There were 61 cases developed early diabetes insipidus (DI), but only 12 cases continue to long-term DI. Seven cases were meningitis. Three cases were death. Out of 83 patients who had preoperative intact hypothalamic-pituitary-adrenal (HPA) axis and hypothalamic pituitary thyroidal (HPT) axis, 2 and 3 of them developed postoperative impair HPA and HPT axis in that order. In addition, among 45 patients who had preoperative impair HPA and HPT axis, 6 of them achieved postoperative endocrinological normalization. Conclusion: In preoperative intact pituitary hormone patients, the total or near total tumor removal of non functioning pituitary adenoma may have hypopituitarism during early postoperative period but gradually returned to normal during 4-6 month postoperative period.

Key-words:

Endoscopic endonasal transsphenoidal tumor removal surgery - nonfunctioning pituitary adenoma - pituitary hormonal status - Prasat Neurological Institute

Financial support and sponsorship

Nil.




Publication History

Received: 06 August 2020

Accepted: 15 October 2020

Article published online:
16 August 2022

© 2021. Asian Congress of Neurological Surgeons. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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