Cardiac T2* magnetic resonance analysis of membranous interventricular septum in assessment of cardiac iron overload in pediatric thalassemia patients: A pilot study

Ishan Kumar; Priyanka Aggarwal; Vineeta Gupta; Ashish Verma; Suwen Kumar; Ram C Shukla

doi:10.4103/ijri.IJRI_395_18

Indian Journal of Radiology and Imaging, Inhaltsverzeichnis

CC BY-NC-ND 4.0 · Indian J Radiol Imaging 2019; 29(01): 33-39
DOI: 10.4103/ijri.IJRI_395_18

Cardiac Radiology

Cardiac T2* magnetic resonance analysis of membranous interventricular septum in assessment of cardiac iron overload in pediatric thalassemia patients: A pilot study

Ishan Kumar

Departments of Radiodiagnosis, Banaras Hindu University, Varanasi, Uttar Pradesh, India

,

Priyanka Aggarwal

Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India

,

Vineeta Gupta

Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India

,

Ashish Verma

Departments of Radiodiagnosis, Banaras Hindu University, Varanasi, Uttar Pradesh, India

,

Suwen Kumar

Department of Cardiology, Queen’s Medical Center, Honolulu, Hawaii, USA

,

Ram C Shukla

Departments of Radiodiagnosis, Banaras Hindu University, Varanasi, Uttar Pradesh, India

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Abstract

Background: Cardiac iron deposition in transfusion-dependent thalassemia patients is patchy in distribution. Purpose: The purpose of this study is to assess the correlation between T2* matrices of membranous interventricular septum (MIVS) and T2* values of muscular interventricular septum (IVS) on magnetic resonance imaging (MRI) and to evaluate the relationship of myocardial T2* at these two locations with MRI-estimated liver iron concentrations (LIC) and electrocardiographic (ECG) parameters. Material and Methods: MRI of heart and liver was performed in 16 consecutive pediatric patients of transfusion-dependent thalassemia major to calculate liver iron concentration and T2* time of membranous and muscular IVS. ECG parameters of these patients were charted and correlated with MRI parameters. Results: No significant correlation between T2* values of muscular IVS and MIVS was observed. Mean T2* of MIVS (9.8 ms) was significantly lower than that of muscular IVS (26.9 ms). T2* of MIVS correlated strongly with LIC where as a weak correlation was observed between T2* of IVS and LIC. Significantly higher mean QTc (corrected QT interval) value (439.86 ms) was seen in patients with T2* IVS <20 ms. Conclusion: Addition of T2* analysis of MIVS to the existing MRI protocol, consisting of muscular IVS analysis, may offer a more sensitive estimation of cardiac iron overload.

Keywords

Cardiac - heart - magnetic resonance imaging - pediatrics - thalassemia

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