PDF herunterladen
CC BY-NC-ND 4.0 · World J Nucl Med 2021; 20(02): 188-191
DOI: 10.4103/wjnm.WJNM_80_20
Case Report

Diffuse bone marrow uptake related to granulocyte colony-stimulating factor-producing maxillary sinus carcinoma on 4-borono-2-18F-fluoro-L-phenylalanine positron emission tomography/computed tomography

Kharisma Kusumahstuti
1   Department of Nuclear Medicine and Tracer Kinetics, Graduate School of Medicine, Osaka University, Osaka, Japan; Department of Nuclear Medicine and Molecular Imaging, Universitas Padjadjaran, General Hasan Sadikin Hospital, Bandung, Indonesia, Japan
2   Department of Nuclear Medicine and Tracer Kinetics, Graduate School of Medicine, Osaka University; Institute for Radiation Sciences, Osaka University, Suita, Osaka, Japan
,
Tadashi Watabe
1   Department of Nuclear Medicine and Tracer Kinetics, Graduate School of Medicine, Osaka University, Osaka, Japan; Department of Nuclear Medicine and Molecular Imaging, Universitas Padjadjaran, General Hasan Sadikin Hospital, Bandung, Indonesia, Japan
3   Department of Oral and Maxillofacial Surgery, Kochi Medical School, Kochi University, Nangoku, Kochi, Japan
,
Naoya Kitamura
4   Department of Oral and Maxillofacial Surgery, Kochi Medical School, Kochi University, Nangoku, Kochi, Japan
,
Tetsuya Yamamoto
4   Department of Oral and Maxillofacial Surgery, Kochi Medical School, Kochi University, Nangoku, Kochi, Japan
› Institutsangaben
› Weitere Informationen
Auch verfügbar auf
   Lizenzen und Reprints

Abstract

Granulocyte colony-stimulating factor (G-CSF) can be produced by tumor cells and is known to promote tumor growth, thereby potentially accelerating disease progression. Squamous cell carcinoma (SCC) at maxillary sinus is aggressive growth with poor prognosis. Maxillary sinus carcinomas are rare and can be clinically silent in the early stages or manifest with the same signs and symptoms of more common illnesses, leading to their delayed diagnosis of disease. Hypermetabolic uptake of 18F-fluorodeoxyglucose (18F-FDG) but not of 4-borono-2-18F-fluoro-L-phenylalanine (18F-FBPA), in the bone marrow of patients with G-CSF-producing tumors without bone marrow involvement during positron emission tomography (PET), has been reported. The present case report describes our first experience of bone marrow uptake in PET/computed tomography examination using 18F-FBPA, high uptake seen in the bone marrow of a patient with a G-CSF-secreting SCC of the maxillary sinus that it relapsed following chemoradiation therapy and surgical resection of the tumor.

Keywords

18F-4-borono-2-18F-fluoro-l-phenylalanine - bone marrow uptake - GSF - maxillary squamous carcinoma

Financial support and sponsorship

This study was funded by the QiSS program of the OPERA (Grant Number: JPMJOP1721) from the Japan Science and Technology Agency.




Publikationsverlauf

Eingereicht: 21. Juli 2020

Angenommen: 13. August 2020

Artikel online veröffentlicht:
24. März 2022

© 2021. Sociedade Brasileira de Neurocirurgia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 

  • References

  • 1 Nagata H, Komatsu S, Takaki W, Okayama T, Sawabe Y, Ishii M, et al. Granulocyte colony-stimulating factor-producing hepatocellular carcinoma with abrupt changes. World J Clin Oncol 2016;7:380-6.
  • 2 Ito N, Matsuda T, Kakehi Y, Takeuchi E, Takahashi T, Yoshida O. Bladder cancer producing granulocyte colony-stimulating factor. N Engl J Med 1990;323:1709-10.
  • 3 Nara T, Hayakawa A, Ikeuchi A, Katoh N, Kishimoto S. Granulocyte colony-stimulating factor-producing cutaneous angiosarcoma with leukaemoid reaction arising on a burn scar. Br J Dermatol 2003;149:1273-5.
  • 4 Iwasa K, Noguchi M, Mori K, Ohta N, Miyazaki I, Nonomura A, et al. Anaplastic thyroid carcinoma producing the granulocyte colony stimulating factor (G-CSF): Report of a case. Surg Today 1995;25:158-60.
  • 5 Nishio N, Fujimoto Y, Hiramatsu M, Maruo T, Tsuzuki H, Mukoyama N, et al. Maxillary sinus carcinoma outcomes over 60 years: Experience at a single institution. Nagoya J Med Sci 2018;80:91-8.
  • 6 Santos MR, Servato JP, Cardoso SV, de Faria PR, Eisenberg AL, Dias FL, et al. Squamous cell carcinoma at maxillary sinus: Clinicopathologic data in a single Brazilian institution with review of literature. Int J Clin Exp Pathol 2014;7:8823-32.
  • 7 Fukuda K, Kojiro M, Hirano M, Hyams VJ, Heffner D. Predominance of squamous cell carcinoma and rarity of adenocarcinoma of maxillary sinus among Japanese. Kurume Med J 1989;36:1-6.
  • 8 Asano S, Urabe A, Okabe T, Sato N, Kondo Y, Ueyama Y, et al. Demonstration of granulopoiesis factor(s) in the plasma of nude mice transplanted with human lung cancer and in the tumor tissue. Blood 1977;49:845-52.
  • 9 Kuroshima T, Wada M, Takehiko S, Takano M, Sed M. G-CSF producing oral carcinoma with diffuse uptake of FDG in the bone marrow: A case report. Oncol Lett 2018;15:1241-5.
  • 10 Herrera MS, González SJ, Minsky DM, Kreiner AJ. Evaluation of performance of an accelerator-based BNCT facility for the treatment of different tumor targets. Phys Med 2013;29:436-46.
  • 11 Ishiwata K, Ido T, Kawamura M, Kubota K, Ichihashi M, Mishima Y. 4-Borono-2-[18F] fluoro-D, L-phenylalanine as a target compound for boron neutron capture therapy: Tumor imaging potential with positron emission tomography. Int J Rad Appl Instrum B 1991;18:745-51.
  • 12 Imahori Y, Ueda S, Ohmori Y, Sakae K, Kusuki T, Kobayashi T, et al. Positron emission tomography-based boron neutron capture therapy using boronophenylalanine for high-grade gliomas: Part I. Clin Cancer Res 1998;4:1825-32.
  • 13 Hanaoka K, Watabe T, Naka S, Kanai Y, Ikeda H, Genki H, et al. FBPA PET in boron neutron capture therapy for cancer: Prediction of 10B concentration in the tumor and normal tissue in a rat xenograft model. EJNMMI Res 2014;4:70.
  • 14 Shimosegawa E, Isohashi K, Naka S, Horitsugi G, Hatazawa J. Assessment of 10B concentration in boron neutron capture therapy; Potential of image-guided therapy using 18FBPA PET. Ann Nucl Med 2016;30:749-55.
  • 15 Watabe T, Hanaoka K, Naka S, Kanai Y, Ikeda H, Aoki M, et al. Practical calculation method to estimate the absolute boron concentration in tissues using 18F-FBPA PET. Ann Nucl Med 2017;31:481-5.
  • 16 Watabe T, Ikeda H, Nagamori S, Wiriyasermkul P, Tanaka Y, Naka S, et al. 18F-FBPA as a tumor-specific probe of L-type amino acid transporter 1 (LAT1): A comparison study with 18F-FDG and11C-Methionine PET. Eur J Nucl Med Mol Imaging 2017;44:321-31.
  • 17 Nakamoto Y, Suga T, Hara T, Ishizu K, Togashi K. Inhomogeneous bone marrow uptake caused by G-CSF mimics multiple bone metastases on FDG-PET. Clin Nucl Med 2010;35:74-6.
  • 18 Kazama T, Swanston N, Podoloff DA, Macapinlac HA. Effect of colony-stimulating factor and conventional-or high-dose chemotherapy on FDG uptake in bone marrow. Eur J Nucl Med Mol Imaging 2005;32:1406-11.
  • 19 Martín L, Comalada M, Marti L, Closs EI, MacLeod CL, Martín del Río R, et al. Granulocyte-macrophage colony-stimulating factor increases L-arginine transport through the induction of CAT2 in bone marrow-derived macrophages. Am J Physiol Cell Physiol 2006;290:C1364-72.
  • 20 Tani H, Kurihara H, Hiroi K, Honda N, Yoshimoto M, Kono Y, et al. Correlation of 18F-BPA and 18F-FDG uptake in head and neck cancers. Radiother Oncol 2014;113:193-7.