The Effects of Vitamin D Supplementation on Biomarkers of Inflammation and Oxidative Stress in Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Mohammad Ali Mansournia; Vahidreza Ostadmohammadi; Amin Doosti-Irani; Majid Ghayour-Mobarhan; Gordon Ferns; Hossein Akbari; Amir Ghaderi; Hamid Reza Talari; Zatollah Asemi

doi:10.1055/a-0630-1303

Hormone and Metabolic Research, Table of Contents

Horm Metab Res 2018; 50(06): 429-440
DOI: 10.1055/a-0630-1303

Review

The Effects of Vitamin D Supplementation on Biomarkers of Inflammation and Oxidative Stress in Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Mohammad Ali Mansournia

¹Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

,

Vahidreza Ostadmohammadi

²Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran

,

Amin Doosti-Irani

³Department of Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran

⁴Modeling of Noncommunicable Diseases Research Center, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran

,

Majid Ghayour-Mobarhan

⁵Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

,

Gordon Ferns

⁶Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex, UK

,

Hossein Akbari

⁷Department of Biostatistics, Kashan University of Medical Sciences, Kashan, Iran

,

Amir Ghaderi

⁸Department of Addiction Studies, School of Medical, Kashan University of Medical Sciences, Kashan, Iran

,

Hamid Reza Talari

⁹Department of Radiology, Kashan University of Medical Sciences, Kashan, Iran

,

Zatollah Asemi

²Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran

› Author Affiliations

Abstract

In this systematic review and meta-analysis of randomized controlled trials (RCTs), the effects of vitamin D supplementation on biomarkers of inflammation and oxidative stress in diabetic patients are summarized. The following databases were searched up to December 2017: MEDLINE, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials. The quality of the relevant extracted data was assessed according to the Cochrane risk of bias tool. Data were pooled using the inverse variance method and expressed as mean difference with 95% Confidence Intervals (95% CI). Heterogeneity between studies was assessed by the Cochran Q statistic and I-squared tests (I²). Overall, 33 studies were included in the meta-analyses. Vitamin D supplementation were found to significantly reduce serum high-sensitivity C-reactive protein (hs-CRP) (WMD 0.27; 95% CI, – 0.35, – 0.20; p<0.001) and malondialdehyde (MDA) levels (WMD – 0.43, 95% CI – 0.62, – 0.25, p<0.001) in diabetic patients. In addition, vitamin D supplementation were found to increase markers of nitric oxide (NO) release (WMD 4.33, 95% CI 0.96, 7.70), total serum antioxidant capacity (TAC) (WMD 57.34, 95% CI 33.48, 81.20, p<0.001) and total glutathione (GSH) levels (WMD 82.59, 95% CI 44.37, 120.81, p<0.001). Overall, this meta-analysis shows that in diabetic patients, taking vitamin D had significant effects on hs-CRP and MDA levels, and significantly increased NO, TAC and GSH levels.

Keywords

vitamin D supplementation - inflammatory markers - oxidative stress - meta-analysis

Full Text

References

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