Orthomolekulare Therapie bei obstruktiven Atemwegserkrankungen

Zusammenfassung

Ungefähr jeder zehnte Deutsche leidet unter Chronic Obstructive Lung Disease (COPD) oder Asthma, wobei beide Krankheiten aufgrund erheblicher klinischer Überlappung häufig gemeinsam vorkommen. Das betrifft auch deren entzündliche Komponente, die Bedeutung der antioxidativen Abwehr und die Gefährdung durch akute und rezidivierende Atemwegsinfektionen. In Prophylaxe und Therapie muss eine gezielte Diagnostik und Supplementation orthomolekularer Substanzen eingebaut werden, besonders die Vitamine C und D sowie Selen, Zink, Magnesium und Omega-3-Fettsäuren.

Abstract

About every 10th German suffers from COPD or asthma, both of which are common due to significant clinical overlap. This also applies to their inflammatory component, the importance of antioxidant defense and the risk of acute and recurrent respiratory tract infections. In prophylaxis and therapy, targeted diagnostic and supplementation of orthomolecular substances must be given, especially vitamins C and D as well as selenium, zinc, magnesium and omega-3 fatty acids.

Schlüsselwörter

Asthma - COPD - orthomolekulare Therapie - Mikronährstoffe - orthomolekulare Diagnostik - Infektprophylaxe

Key words

Asthma - COPD - orthomolecular therapy - micronutrients - orthomolecular diagnostics - infection prophylaxis

• Literatur

• 1 Allen S, Britton J, Leonardi-Bee J. Association between antioxidant vitamins and asthma outcomes: systematic review and metaanalysis. Thorax. 2009
• 2 Ali NS, Nanji K. A review on the role of vitamin D in asthma. Cureus 2017; 29 9 (05) e1288 DOI: 10.7759/cureus.1288
• 3 Atlantis E, Cochrane B. The association of dietary intake and supplementation of specific polyunsaturated fatty acids with inflammation and functional capacity in chronic obstructive pulmonary disease: a systematic review. Int J Evid Based Healthcare 2016; 14: 53-63
• 4 Avenell A, Cook JA, Maclennan GS. et al. Vitamin D supplementation to prevent infections: a sub-study of a randomised placebo-controlled trial in older people (RECORD trial, ISRCTN 51647438). Age Ageing 2007; 36: 574-577
• 5 Aziz HS. Serum magnesium levels and acute exacerbations of chronic obstructive pulmonary disease: a retrospective study. Ann Clin Lab Sci 2005; 35: 423-427
• 6 Bergman P, Lindh AU, Björkhem-Bergman L. et al. Vitamin D and Respiratory Tract Infections: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. PLoS ONE 2013; 8: e65835
• 7 Bergman P. et al. Vitamin D supplementation to patients with frequent respiratory tract infections: a post hoc analysis of a randomized and placebo-controlled trial. BMC Research Notes 2015; 8: 391
• 8 Borghi-Silva A. et al. L-carnitine as an ergogenic aid for patients with chronic obstructive pulmonary disease submitted to whole-body and respiratory muscle training programs. Braz J Med Biol Res 2006; 39: 465-74
• 9 Cheuk DKL, Chau TCH, Lee SL. A meta-analysis on intravenous magnesium sulphate for treating acute asthma. Archives of disease in childhood 2005; 90: 74-77
• 10 Colomer R, Moreno-Nogueira JM, García-Luna PP. et al. N-3 fatty acids, cancer and cachexia: a systematic review of the literature. Br J Nutr 2007; 97: 823-831
• 11 Fabian E, Pölöskey P, Kósa L. et al. Nutritional supplements and plasma antioxidants in childhood asthma. Wiener klinische Wochenschrift 2013; 125: 309-315
• 12 Gazdík F, Gvozdjáková A, Nádvorníková R. et al. Decreased levels of coenzyme Q (10) in patients with bronchial asthma. Allergy 2002; 57: 811-4
• 13 Ginde AA. et al. Association between serum 25-hydroxy vitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey. Arch Intern Med 2009; 169: 384-390
• 14 Giudetti M, Cagnazzo R. Beneficial effects of n-3 PUFA on chronic airway inflammatory diseases. Prostaglandins Other Lipid Mediat 2012; 99: 57-67
• 15 Gröber U. Atemwegsinfektionen und Mikronährstoffe. EHK 2013; 62: 181-186
• 16 Herr C, Greulich T, Koczulla RA. et al. The role of vitamin D in pulmonary disease: COPD, asthma, infection, and cancer. Respiratory Research 2011; 12: 31
• 17 Isbaniah F. et al. Echinacea purpurea along with zinc, selenium and vitamin C to alleviate exacerbations of chronic obstructive pulmonary disease: results from a randomized controlled trial. Journal of clinical pharmacy and therapeutics,. 2011 5. 568-576
• 18 Johnstone J, Roth DE, Guyatt G. et al. Zinc for the treatment of the common cold: a systematic review and meta-analysis of randomized controlled trials. Canadian Med Ass Jour. 2012 cmaj-111990
• 19 Jolliffe DA, Greenberg L, Hooper RL. et al. Vitamin D supplementation to prevent asthma exacerbations: a systematic review and meta-analysis of individual participant data. The Lancet Resp Med 2017; 5: 881-890
• 20 Kim DJ. et al. Magnesium intake in relation to systemic inflammation, insulin resistance, and the incidence of diabetes. Diabetes Care 2010; 33: 2604-2610
• 21 Kırkıl G. et al. Antioxidant effect of zinc picolinate in patients with chronic obstructive pulmonary disease. Resp med 2008; 102: 840-844
• 22 Laaksi I, Ruohola JP, Tuohimaa P. et al. An association of serum vitamin D concentrations < 40 nmol/L with acute respiratory tract infection in young Finnish men. Am J Clin Nutr 2007; 86: 714-717
• 23 Laaksi I, Ruohola JP, Mattila V. et al. Vitamin D supplementation for the prevention of acute respiratory tract infection: a randomized, double-blinded trial among young Finnish men. J Infect Dis 2010; 202: 809-814
• 24 Lahousse L, Seys LJ, Joos GF. et al. Epidemiology and impact of chronic bronchitis in chronic obstructive pulmonary disease. Europ Resp J 2017; 50: 1602470
• 25 Lin Y. et al. Supplementation of fish oil improves functional capacity and quality of life in patients with chronic obstructive pulmonary disease. Current Topics in Nutra Res 2016; 14: 191-197
• 26 Lorenz J. Respirationstrakt – Ernährung bei chronisch obstruktiver Atemwegserkrankung und bei Asthma. In: Biesalski HK, Fürst P, Kasper H. et al., Hrsg. Ernährungsmed. 1995: 327-328
• 27 Martineau AR. et al. Vitamin D 3 supplementation in patients with chronic obstructive pulmonary disease (COPD): a multicentre, double blind, randomised controlled trial. The lancet Resp med 2015; 120-130
• 28 Mazur A. et al. Magnesium and the inflammatory response: potential physiopathological implications. Arch Biochem Biophys 2007; 458: 48-56
• 29 Nielsen FH, Johnson LK, Zeng H. Magnesium supplementation improves indicators of low magnesium status and inflammatory stress in adults older than 51 years with poor quality sleep. Magnes Res 2010; 23: 158-168
• 30 Nurmatov U, Devereux G, Sheikh A. Nutrients and foods for the primary prevention of asthma and allergy: systematic review and meta-analysis. J of Allergy and Clin Immunol 2011; 127: 724-733
• 31 Persson LJ. et al. Vitamin D, Vitamin D Binding Protein, and Longitudinal Outcomes in COPD. PLoS One 2015; 10: e0121622
• 32 Prakash S. et al. Serum magnesium is an independent predictor of frequent readmissions due to acute exacerbation of chronic obstructive pulmonary disease. Resp Med 2008; 102: 999-1003
• 33 Prasad AS. et al. Zinc supplementation decreases incidence of infections in the elderly: effect of zinc on generation of cytokines and oxidative stress. The American J of clinical nutrition 2007; 85: 837-844
• 34 Rees JR, Hendricks K, Barry EL. et al. Vitamin D3 supplementation and upper respiratory tract infections in a randomized, controlled trial. Clin Infect Dis 2013; 57: 1384-1392
• 35 Richter V, Hamm M. Omega-3-Fettsäuren und Resolvine: Implikationen für die Atheroskleroseprävention. Perfusion 2012; 25: 144-151
• 36 Schilling S. Epidemic vitamin D deficiency among patients in an elderly care rehabilitation facility. Dtsch Ärztebl Int 2012; 109: 33-38
• 37 Schöttker B, Haug U, Schomburg L. et al. Strong associations of 25-hydroxyvitamin D concentrations with all-cause, cardiovascular, cancer, and respiratory disease mortality in a large cohort study. Am J Clin Nutr 2013; 97: 782-793
• 38 Suissa S, Dell’Aniello S, Ernst P. Long-term natural history of chronic obstructive pulmonary disease: severe exacerbations and mortality. Thorax 2012; 67: 957-963
• 39 Tran B, Armstrong BK, Ebeling PR. et al. Effect of vitamin D supplementation on antibiotic use: a randomized controlled trial. Am J Clin Nutr 2014; 99: 156-161
• 40 Vormann J. Physiologie und Pathophysiologie von Magnesium. Schw Zeitschr Ernährungsmed 2010; 1: 8-13
• 41 Wey S. L-Carnitin – Porträt einer Aminosäure. Z Orthomol Med 2015; 2: 19-22
• 42 Zittermann A, Pilz S, März W. Vitamin D und Infektanfälligkeit. Akt Ernahrungsmed 2015; 40: 240-246
• 43 Zhu M. et al. The association between vitamin D and COPD risk, severity, and exacerbation: an updated systematic review and meta-analysis. Int J Chron Obstruct Pulmon Dis 2016; 11: 2597-2607